欢迎登录材料期刊网

材料期刊网

高级检索

以共沉淀法与离子交换法制备丙戊酸钠插层Mg/Al-NO3-LDH,结合XRD、FT-IR、TG-DTA分析表明,丙戊酸钠进入LDH层间与层板相互作用形成超分子结构,使丙戊酸钠的热稳定性提高近100℃.提出了以共沉淀法制备丙戊酸钠插层Mg/Al-NO3-LDH,在LDH形成层板结构的过程中,形成中间态--溶胶-凝胶态,与离子交换法相比更易于客体进入层间.缓释实验表明,共沉淀法制备的产物具有良好的缓释性.

参考文献

[1] 雷立旭,张卫锋,胡猛,Dermot O'Hare.层状复合金属氢氧化物:结构、性质及其应用[J].无机化学学报,2005(04):451-463.
[2] 刘红霞,段雪,马润宇.层状材料水滑石固定青霉素酰化酶的研究[J].北京化工大学学报(自然科学版),2002(03):9-11,16.
[3] 吴祥根,朱建芬,高永良.新型医药用载体--层状双金属氢氧化物[J].中国药学杂志,2006(05):327-330.
[4] 倪哲明,夏盛杰,王力耕,邢方方,潘国祥,胡军.诺氟沙星插层镁铝水滑石新型药物-无机复合材料的超分子结构、热稳定性和缓释性能[J].高等学校化学学报,2007(07):1214-1219.
[5] Tammaro L;Costantino U;Bolognese A;Sammartino G;Marenzi G;Calignano A;Tete S;Mastrangelo F;Califano L;Vittoria V .Nanohybrids for controlled antibiotic release in topical applications[J].International journal of antimicrobial agents,2007(4):417-423.
[6] Mohanambe L;Vasudevan S .Anionic clays containing anti-inflammatory drug molecules:Comparison of molecular dynamics simulation and measurements[J].Journal of Physical Chemistry B,2005,109:15651.
[7] Gordijo CR;Da Costa Ferreira AM;Oliveira Silva DD .Immobilization of ibuprofen and copper-ibuprofen drugs on layered double hydroxides.[J].Journal of Pharmaceutical Sciences,2005(5):1135-1148.
[8] Trikeriotis M;Ghanotakis DF .Intercalation of hydrophilic and hydrophobic antibiotics in layered double hydroxides.[J].International Journal of Pharmaceutics,2007(1/2):176-184.
[9] 孙伟张,曾仁杰,景莉,张勤,钟莉.丙戊酸钠缓释片的制备及其释放度的测定[J].华西药学杂志,2003(04):271-272.
[10] Khan AI.;O'Hare D. .Intercalation chemistry of layered double hydroxides: recent developments and applications[J].Journal of Materials Chemistry: An Interdisciplinary Journal dealing with Synthesis, Structures, Properties and Applications of Materials, Particulary Those Associated with Advanced Technology,2002(11):3191-3198.
[11] Lopez T;Bosh P;Ramos E .Synthesis and characterization of sol-gel hydrotalcites structure and texture[J].Langmuir,1996,12(01):189.
[12] Zhang H;Zou K;Guo SH;Duan X .Nanostructural drug-inorganic clay composites: Structure, thermal property and in vitro release of captopril-intercalated Mg-Al-layered double hydroxides[J].International Journal of Quantum Chemistry,2006(6):1792-1801.
[13] Ambrogi V;Fardella G;Grandolini G;Perioli L .Intercalation compounds of hydrotalcite-like anionic clays with antiinflammatory agents--I. Intercalation and in vitro release of ibuprofen.[J].International Journal of Pharmaceutics,2001(1/2):23-32.
[14] Ambrogi V et al.Intercalation compounds of hydrotalcite-like anionic clays with anti-inflammatory agents,Ⅱ:Uptake of diclofenac for a controlled release formulation[J].AAPS Pharm Sci Techn,2002,3(03):26.
[15] 孟锦宏,张慧,David G.Evans,段雪.新型层状农药缓/控释材料--草甘膦插层双金属氢氧化物的超分子结构与缓释性能[J].科学通报,2005(03):208-214.
上一张 下一张
上一张 下一张
计量
  • 下载量()
  • 访问量()
文章评分
  • 您的评分:
  • 1
    0%
  • 2
    0%
  • 3
    0%
  • 4
    0%
  • 5
    0%