高LET重离子引起的集簇性DNA损伤会造成细胞突变、癌变和凋亡。促进肿瘤细胞凋亡一直是治愈肿瘤的出发点,所以集簇性DNA损伤已经成为放射生物学领域研究的热点问题。由于其提取和检测方法多样,但并没有一个详细和完整的方案对集簇性DNA损伤进行透彻分析。综述了集簇性DNA损伤的特点和详细讨论了集簇性DNA损伤最新研究进展,简介了集簇性DNA损伤的研究方法,以期为集簇性DNA损伤在放疗中的研究提供一些参考。
Clustered DNA damage which caused by high LET heavy ion radiation can lead to mutation, tu- morigenesis and apoptosis. Promoting apoptosis of cancer cells is always the basis of cancer treatment. Clustered DNA damage has been the hot topic in radiobiology. The detect method is diversity, but there is not a detail and complete protocol to analyze clustered DNA damage. In order to provide reference for clus- tered DNA damage in the radiotherapy study, the clustered DNA damage characteristics, the latest pro- gresses on clustered DNA damage and the detecting methods are reviewed and discussed in deteil in this paper.
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