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对12C6+离子辐照诱变高产阿维链霉菌株ZJAV-Y1-203和原始菌株ZJAV-A-1的摇瓶发酵pH值、菌体浓度、碳源和氮源代谢进行了测定,研究了12C6+辐照对阿维链霉菌的代谢效应。在发酵前期(48 h),原始菌株发酵液pH值低于突变菌株;在发酵96~196 h,诱变高产菌株ZJAV-Y1-203繁殖快,生长旺盛,N的利用率高;菌体浓度大于原始菌株的浓度,且发酵液的pH稳定,菌体处于代谢相对更稳定期;在发酵144~240 h,诱变高产菌株ZJAV-Y1-203对糖源消耗低于原始菌株ZJAV-A-1。这些结果表明,12C6+离子辐照对阿维链霉菌代谢影响有利于阿维菌素合成。

10.11804/NuclPHysRev.30.02.195

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