通过研究141种对7种水生生物（发光菌、江水细菌、绿藻、大型溞、鲤鱼、黑头呆鱼，古比鱼）的毒性，建立了非极性麻醉型和极性麻醉型有机物的毒性与辛醇／水分配系数的对数lgKow的相关性，并对该相关性进行了理论解释。同时，建立了Abraham参数与7种水生生物毒性的预测模型，根据Abraham参数和预测模型的系数，对有机污染物与生物毒性作用机理进行了理论分析。在此基础上，对Abraham毒性模型回归系数进行主成分分析，发现有机污染物对7种水生生物的毒性机理具有一定种间相似性和种间差异性，通过有机污染物对7种水生生物种间相关性研究发现，近缘物种种间具有良好的相关性，说明这些物种具有较相似的毒性作用机理，而非近缘物种种间相关性较差，说明这些物种种间毒性机理存在一定差异。
The toxicities of 141 organic pollutants to seven aquatic organisms ( Vibrio fischeri, River bacteria, Scenedesmus obliguue, Daphnia magna, Cyprinuscarpio, Pimephalespromelas, Poeciliareticulata) were analyzed. A linear relationship between the toxicity data of non?polar or polar narcotics and hydrophobicity (lgKow) was established for the seven species, respectively. This relationship was interpretated based on the theoretical consideration. Meanwhile, quantitative structure?activity relationship ( QSAR) studies were performed between the toxicities of seven aquatic organisms and Abraham descriptors. The mechanisms of action to seven species were analyzed theoretically based on Abraham descriptors and model coefficients. The principal component analysis carried out on the regression coefficients of Abraham models shows that there are interspecies similarities and differences between the species. In the same time, the interspecies correlation of organic pollutants to seven aquatic organisms was analyzed. The results show that there are good interspecies corrections between fish species, marine bacterium and fish or daphnia magna and fish. It is suggested that some compounds shared the same toxic mechanism of action between the species. However , poor interspecies relationships found between toxicities to algae and daphnia magna or fish suggested that compounds have different toxic mechanism of action between these species.
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