细胞低剂量辐射反应是目前国际上研究的热点.介绍了哺乳动物细胞的低剂量反应--辐射超敏感性(HRS)和增强的辐射抗性(IRR),即细胞在大约0.1 Gy时会出现单位剂量细胞杀伤增强现象,随着剂量的升高,细胞的IRR增强,到1 Gy以上细胞存活符合线性平方模型.评述了近年来国际上低剂量HRS领域的研究进展,着重讨论了HRS/IRR可能的分子机理及辐射传能线密度与HRS/IRR的关系,并对HRS/IRR在肿瘤临床放射治疗中的应用做了初步的探讨,最后提出了该领域进一步研究的一些问题.
参考文献
| [1] | Puck T T,Marcus P I.J Exp Med,1956,103:653. |
| [2] | Spadinger I,Palcic B.Int J Radiat Biol,1993,63:183. |
| [3] | Wouters B G,Skarsgard L D.Radiat Res,1994,138:S76. |
| [4] | Marples B,Joiner M C.Radiat Res,1993,133:41. |
| [5] | Short S,Mayes C,Woodcock M,et al.Int J Radiat Biol,1999,75:847. |
| [6] | Jin X D,Li Q,Li W J.Nucl Instr and Meth,2006,B245:310. |
| [7] | Short S,Woodcock M,Marples B,et al.Int J Radiat Biol,2003,79:99. |
| [8] | Xia S X.Radiobiology.Beijing:Military Medical Sciences Press,1998,60(in Chinese).(夏寿萱.放射生物学.北京:军事医学科学出版社,1998,60.) |
| [9] | Jeggo P A.Adv in Gene,1998,38:185. |
| [10] | Marples B,Joiner M C.Radiat Res,1995,141:160. |
| [11] | Rothkamm K,Lobrich M.Proc Natl Acad Sci USA,2003,100:5 057. |
| [12] | Herceg Z,Wang Z Q.Mutat Res,2001,477:97. |
| [13] | Chalmers A,Johnston P J,Woodcock M,et al.Oncol Biol Phys,2004,58:410. |
| [14] | Bakkenist C J,Kastan M B.Nature,2003,421:499. |
| [15] | Wykes S M,Piasentin E,Joiner M C,et al.Radiat Res,2006,165:516. |
| [16] | Jakob B,Scholz M,Taucher-Scholz G.Rad Res,2000,154:398. |
| [17] | Jakob B,Scholz M,Taucher-Scholz G.Int J Radiat Biol,2002,78:75. |
| [18] | Taucher-Scholz G,Jakob B,Becker G,et al.Nucl Instr and Meth,2003,B209:270. |
| [19] | Mrples B,Wouters B G,Joiner M C.Radiat Res,2003,160:38. |
| [20] | Zhou B B,Elledge S J.Nature,2002,,408:433. |
| [21] | Mrples B,Wouters B G,Joiner M C.Radiat Res,2003,160:38. |
| [22] | Xu B,Kim S,Kastan M B.Mol Cell Biol,2002,22:1 049. |
| [23] | Jeggo P A.Radiat Res,1998,150:580. |
| [24] | Thacker J.CR Acad Sci Paris,1999,322:103. |
| [25] | Featherstone C,Jackson S P.Current Biology,1999,9:759. |
| [26] | Skov K,Marples B,Matthews J B,et al.Radiat Res,1994,138(Suppl):S126. |
| [27] | Marples B,Cann N E,Mithell C R,et al.Int J Radiat Biol,2002,78:1 139. |
| [28] | Michalik V.Radiat Prote and Dosim,1994,52:245. |
| [29] | Hoglund E,Blomquist E,Carlsson J,et al.Int J Radiat Biol,2000,76:539. |
| [30] | Lobrich M,Cooper P,Rydberg B.Int J Radiat Biol,1996,70:493. |
| [31] | Newman H,Prise K,Folkard M,et al.Int J Radiat Biol,1997,71:347. |
| [32] | Karaxenberage F,Weber K J,Friedl A A,et al.Radiat and Envi Bio1,1998,37:107. |
| [33] | Hoglund E,Stenerlow B.Radiat Res,2001,155:818. |
| [34] | Zhai Z H.Cell Biology.Beijing:Higher Education Press,2000,270(in Chinese).(翟中和.细胞生物学.北京:高等教育出版社,2000,270.) |
| [35] | Marples B,Lam G K,Zhou H,et al.Radiat Res,1994,138:S81. |
| [36] | Lambin P,Marples B,Fertil B,et al.Int J Radiat Biol,1993,63:639. |
| [37] | Bohrnsen G,Weber J K,Scholz M.Int J Radiat Biol,2002,78:259. |
| [38] | Jin X D,Li Q,Li W J,et al.Nuclear Physics Review,2005,22(2):208 (in Chinese).(金晓东,李强,李文建等.原子核物理评论,2005,22(2):208.) |
| [39] | Short S.Gray Lab Research Report,London:1999,151. |
| [40] | Beauchesne P D,Bertrand S,Branche R,et al.Int J Cancer,2003,105:33. |
| [41] | Krause M,Hessel F,Wohlfarth J,et al.Int J Radiat Biol,2003,179:377. |
| [42] | Joiner M C,Denekamp J,Maughan R L,Int J Radiat Biol Related Studies Phys Chem Med,1986,49:565. |
| [43] | Joiner M C,Johns H.Radiat Res,1988,114:385. |
| [44] | Parkins C F,Fowler J.Br J Cancer,1986,7(Suppl):320. |
| [45] | Wong C S,Minkin S,Hill R P.Radiotheray Oncol,1992,23:176. |
| [46] | Hamilton C S,Denham J W,O'Brien M,et al.Radiotheray Oncol,1996,40:23. |
| [47] | Harney J,Short C,ShahN,et al.Int J Rad Onc Biol Phys,2004,59:1 190. |
| [48] | Short S,Kelly J,Woodcock M,et al.Int J Radiat Biol,2001,77:655. |
| [49] | Jin X D,Li Q,Guo C L,et al.Nuclear Pnysics Review,2006,23(2):42(in Chinese).(金晓东,李强,郭传玲等.原子核物理评论,2006,23(2):42.) |
| [50] | Maples B,Wouters B G,Collis S J,et al.Radiat Res,2004,161:247. |
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