列举了一些具有代表性的研究结果, 概括介绍了一些产生旁观者效应的可能机制以及辐照引起的活性氧基团或分子、细胞通讯和细胞因子在旁观者效应中的重要作用. 此外, 还讨论了旁观者效应的表达程度与辐照剂量和射线品质的关系. 旁观者效应的研究结果表明: 辐射产生的潜在危害可能要比以前估计的大, 这给如何评估辐射对人类造成的危害带来了新的冲击.
参考文献
[1] | Moolten F L. Tumour Chemosensitivity Conferred by Inserted Herpes Thymidine Kinase Genes: Paradigm for a prospective cancer control strategy[J]. Cancer Res, 1986, 46: 5 276. |
[2] | Nagasawa H, Little J B. Induction of Sister Chromatid Exchanges by Extremely Low Dose of α-particles[J]. Cancer Res, 1992, 52: 6 394. |
[3] | Nagasawa H, Little J B. Unexpected Sensitivity to the Induction of Mutation by very Low Doses of Alpha-particle Radiation: Evidence for abystander effect[J]. Radiat Res, 1999, 152: 552. |
[4] | Deshpande A, Goodwin E H, Bailey S M, et al. Alpha-particle-induced Sister Chromatid Exchange in Normal Human Lung Fibroblasts: Evidence for an extranuclear target[J]. Radiat Res, 1996, 145: 260. |
[5] | Wu L-J, Randers-Pehrson G, Xu A, et al. Targeted Cytoplasmic Irradiation with Alpha Particles Induces Mutation in Mammalian Cells[J].Proc Natl Acad Sci USA,1999, 96: 4 959. |
[6] | Prise K M, Belyakov O V, Folkard M, et al. Studies of Bystander Effects in Human Fibroblasts Using a Charged Particle Microbeam[J]. Int J Radiat Biol, 1998, 74: 793. |
[7] | Belyakov O V, Prise K M, Trott K R, et al. Delayed Lethality, Apoptosis and Micronucleus Formation in Human Fibroblasts Irradiated with X-rays or α-particles[J]. Int J Radiat Biol, 1999, 75: 985. |
[8] | Seymour C B, Mothersill C. Delayed Expression of Lethal Mutations and Genomic Instability in the Progeny of Human Epithelial Cells that Survived in a Bystander-killing Environment[J]. Radiat Oncol Invest, 1997, 5: 106. |
[9] | Sawant S G, Randers-Pehrson G, Geard C R, et al. The Bystander Effect in Radiation Oncogenesis: I Transformation in C3H 10T1/2 cells in vitro can be initiated in the unirradiated neighbors of irradiated cells[J]. Radiat Res, 2001, 155: 397. |
[10] | Lehnert B E, Goodwin E H. Extracelluar Factor(s) Following Exposureto α-particles can Cause Sister Chromatid Exchanges in Normal Human Cells[J]. Cancer Res, 1997, 57: 2 164. |
[11] | Narayanan P K, Goodwin E H, Lehnert B E. α-particles Initiate Biological Production of Superoxide Anions and Hydrogen Peroxide in Human Cells[J]. Cancer Res, 1997, 57: 3 969. |
[12] | Pitts J D. Cancer Gene Therapy: A bystander effect using the gap junctional pathway[J]. Mol Carcinogen,1994 11: 127. |
[13] | Diber M S, Abedi M R, Christensson B. Gap Junctions Promote the Bystander Effect of Herpes Simplex virus Thymidine Kinase in Vivo[J]. Cancer Res, 1997, 57: 1 523. |
[14] | 翟中和, 王喜中, 丁明孝主编. 细胞生物学[M]. 北京: 高等教育出版社, 2000, 124-129. |
[15] | Azzam E I, Toledo S M, Gooding T, et al. Intercellular Communication Is Involved in the Bystander Regulation of Gene Expression in Human Cells Exposed to very Low Fluences of Alpha Particles[J]. Radiat Res, 1998, 150: 497. |
[16] | Bishayee A, Dandamudi V R. Evidence for Pronounced Bystander Effects Caused by Nonuniform Distributions of Radioactivity Using a Novel Three-dimensional Tissue Culture Model[J]. Radiat Res, 1999, 152: 88. |
[17] | Morgen W F, Hartmann A, Limoli C L, et al. Bystander Effects in Radiation-induced Genomic Instability, Mutation Research[J]. 2002, 504: 91. |
[18] | Mothersill C, Seymour C B. Medium from Irradiated Human Epithelial Cells but not Human Fibroblasts Reduces the Clonogenic Survival of Unirradiated Cells[J]. Int J Radiat Biol, 1997, 71: 421. |
[19] | Mothersill C, Seymour C B. Cell-cell Contact During Gamma Irradiation Is not Required to Induce a Bystander Effect in Normal Human Keratinocytes: Evidence for release during irradiation of a signal controlling survival into medium[J]. Radiat Res, 1998, 149: 256. |
[20] | Lyer R, Lehnert B E. Factors Underlying the Cell Growth-related Bystander Responses to α-particles[J]. Cancer Res, 2000, 60: 1 290. |
[21] | Narayanan P K, LaRue K E, Goodwin E H, et al. α-particles Induce the Production of Interleukin-8 by Human Cells[J]. Radiat Res, 1999, 152: 57. |
[22] | Limoli C L, Hartman A, Shephard L, et al. Apoptosis, Reproductive Failure, and Oxidative Stress in Chinese Hamster Ovary Cells with Compromised Genomic Integrity[J]. Cancer Res, 1998, 58: 3 712. |
[23] | Shao C L, Aoki M, Furusawa Y. Medium-mediated Bystander Effects on HSG Cells Co-cultivated with Cells Irradiated by X-rays or a 290 MeV/u Carbon Beam[J]. J Radiat Res, 2001, 42: 305. |
[24] | Lyer R, Lehnert B E. Low Dose, Low-LET Ionizing Radiation-induced Radioadaptation and Associated Early Responses in Unirradiated Cell[J]. Mut Research, 2002, 503: 1. |
[25] | Nagasawa H, Little J B. Bystander Effect for Chromosomal Aberrations Induced in Wild-type and Repair Deficient CHO Cells by Low Fluencies of Alpha Particles[J]. Mut Res, 2002, 508: 121. |
[26] | Nagasawa H, Huo L, Little J B. Increased Bystander Mutagenic Effect in DNA Double-strand Break Repair-deficient Mammalian Cells[J]. Int J Radiat Biol, 2002, 100: 1. |
[27] | Ballarini F, Biaggi M, Ottolenghi A, et al. Cellular Communication and Bystander Effects: A critical review for modeling low-dose radiation action[J]. Mut Res, 2002, 501: 1. |
[28] | Seymour C B, Mothersill C. Relative Contribution of Bystander and Targeted Cell Killing to the Low Dose Region of the Radiation Dose-response Curve[J]. Radiation Research, 2000, 153: 508. |
[29] | Watson G E, Lorimore S A, Macdonald D A, et al. Chromosomal Instability in Unirradiated Cells Induced in vivo by a Bystander Effect of Ionizing Radiation[J]. Cancer Research, 2000, 60: 5 608. |
[30] | Lorimore S A, Coates P J, Scobie G E, et al. Inflammatory-type Responses after Exposure to Ionizing Radiation in Vivo: A mechanism for radiation-induced bystander effects [J]. Oncogene, 2001, 20: 7 085. |
[31] | Brenner D J, Sachs R K. Do Low Dose-rate Bystander Effects Influence Domestic Radon Risks [J]. Int J Radiat Biol, 2002, 78: 593. |
[32] | 杨垂绪(美), 梅蔓彤(中). 太空放射生物学[M]. 广州: 中山大学出版社, 1995, 1-20. |
[33] | Nagar S, Smith L E, Morgan W F. Characterization of a Novel Epigenetic Effect of Ionizing Radiation: The death-inducing effect[J].Cancer Res, 2003, 63: 324. |
[34] | Zhou H, Suzuki M, Geard C R, et al. Effects of Irradiation Medium with or without Cells on Bystander Cell Responses[J]. Mut Res, 2002, 499: 135. |
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