用原子力显微镜(AFM)观察了液晶态LB膜和脂质体形貌的结构和稳定性.实验结果表明,在扫描区域内,对于DOPE脂质体,可观察到一些由DOPE超分子聚集体形成的大小不同的球形颗粒;对于DOPE和DOPC混合脂质体,则不仅观察到类似脂质体的球形颗粒,而且也观察到了双层膜结构, 其厚度约为5～6nm.随着NaCl浓度的增加,它们的双层膜更稳定.葡萄糖和蔗糖对脂双层膜结构有稳定作用.
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