生物材料表面固定催化活性分子,催化内源性供体释放一氧化氮(NO),能显著改善材料表面的血液相容性.通过聚多巴胺作为中间连接层,在TiO2薄膜表面固定不同手性的L-型或D-型胱氨酸钠获得催化活性表面,研究固定不同手性胱氨酸钠表面对改善血小板激活行为的影响.X射线光电子能谱(X-ray photoelectron spectroscopy,XPS)和水接触角检测结果显示,在相同工艺条件下表面固定L-型或D-型胱氨酸钠后物理化学性质相近,而两种表面的生物学性质却存在较大差异,固定D-型表面预先吸附白蛋白后表面亲水性略有增加但标准偏差较大,而固定L-型表面催化释放NO的能力和抗血小板的激活性能均优于固定D-型表面.
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