利用多壁碳纳米管为药物载体，采用酸化处理改进了材料表面的亲疏水性及在溶液中的分散性，叶酸改性壳聚糖修饰的碳纳米管表面，以布洛芬为模型药物，重点考察了其组装与缓释性能。研究表明，随着布洛芬药物浓度的增加，负载药物的速率加快，载药量也随之增加；温度对载药量无明显影响；叶酸改性壳聚糖修饰的碳纳米管无突释现象，是理想的药物载体；随着介质离子浓度的增大，释药速率加快，释药量增加。
Using multi-walled carbon nanotubes as drug carriers,the hydrophobicity and dispersion property in the solution of the materials have been improved by acidizing.The carbon nanotubes were modified by chitosan with folic acid and the ibuprofen was as the model drug.The study was mainly focused on the loaded and release property.The results show that the rate of loading drugs accelerate and the drug-loading amount increases with the increases of ibuprofen concentration.The temperature has no obvious effect on the loaded property.There was no sudden slow-release phenomenon in the ibuprofen which loaded in the carbon nanotubes modified by chi-tosan with folic acid system.And the carbon nanotubes are the ideal for pharmaceutical carriers.With the in-crease of concentration of medium,the drug release rate is accelerated and the release drug quantity also increa-ses.
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