采用甘油为增塑剂对海藻酸钙海绵进行改性处理,制备了可用作伤口敷料的柔性海绵.结果表明,改性后海藻酸钙海绵的柔韧性增强,可任意弯折,表面光滑平整,不易碎,摩擦不掉渣,能同时满足医用伤口敷料的功能性和舒适性的要求.随着甘油含量的增加,海绵的柔韧性增强,断裂延伸率和对蒸馏水的保波量增加,但是海绵的断裂强度、初始模量、孔隙率、透气率和吸液量下降.海藻酸钙海绵的最佳增塑工艺为甘油浓度6％,处理时间12h,处理温度30℃,此时其柔软度指标为326.8°,断裂强度为0.376MPa,孔隙率为82.3％,透气率为59.8％,对蒸馏水的吸液量和保液量为13.1和6.73g/g.
参考文献
| [1] | Huang Zhihai;Yang Lei;Dong Yinsheng et al.Fabrication of chitosan sponge as dressings by phase separationextraction method[J].The Chinese Journal of Nonferrous Metals,2007,17(special i):268-274. |
| [2] | Chun-Mei Deng;Lan-Zhen He;Ming Zhao .Biological properties of the chitosan-gelatin sponge wound dressing[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2007(3):583-589. |
| [3] | Ozturk E;Agalar C;Kececi K;Denkbas EB .Preparation and characterization of ciprofloxacin-loaded alginate/chitosan sponge as a wound dressing material[J].Journal of Applied Polymer Science,2006(3):1602-1609. |
| [4] | Jayakumar, R.;Prabaharan, M.;Kumar, P. T. Sudheesh;Nair, S. V.;Tamura, H. . .Biomaterials based on chitin and chitosan in wound dressing applications[J].Biotechnology Advances: An International Review Journal,2011(3):322-337. |
| [5] | Mi FL;Shyu SS;Wu YB;Lee ST;Shyong JY;Huang RN .Fabrication and characterization of a sponge-like asymmetric chitosan membrane as a wound dressing.[J].Biomaterials,2001(2):165-173. |
| [6] | Kim HJ;Choi EY;Oh JS;Lee HC;Park SS;Cho CS .Possibility of wound dressing using poly(L-leucine)/poly(ethylene glycol)/poly(L-leucine) triblock copolymer.[J].Biomaterials,2000(2):131-141. |
| [7] | 顾其胜,朱彬.海藻酸盐基生物医用材料[J].中国组织工程研究与临床康复,2007(26):5194-5198. |
| [8] | Zhao L;Weir MD;Xu HH .An injectable calcium phosphate-alginate hydrogel-umbilical cord mesenchymal stem cell paste for bone tissue engineering.[J].Biomaterials,2010(25):6502-6510. |
| [9] | Silvia J. Bidarra;Cristina C. Barrias;Mario A. Barbosa .Immobilization of Human Mesenchymal Stem Cells within RGD-Grafted Alginate Microspheres and Assessment of Their Angiogenic Potential[J].Biomacromolecules,2010(8):1956-1964. |
| [10] | 刘杨,任力,季培红,王迎军.海藻酸钠的提纯及海藻酸钙多孔支架的制备[J].华南理工大学学报（自然科学版）,2012(07):142-147. |
| [11] | Lai HL;Abu'Khalil A;Craig DQ .The preparation and characterisation of drug-loaded alginate and chitosan sponges.[J].International Journal of Pharmaceutics,2003(1/2):175-181. |
| [12] | Shapiro L.;Cohen S. .NOVEL ALGINATE SPONGES FOR CELL CULTURE AND TRANSPLANTATION[J].Biomaterials,1997(8):583-590. |
| [13] | 张传杰,徐琪,熊春华,冉建华,刘云,朱平.海藻酸钙海绵的结构与性能[J].高分子材料科学与工程,2012(09):24-27. |
| [14] | 秦益民.新型医用敷料：伤口种类及其对敷料的要求（Ⅰ）[J].纺织学报,2003(05):113-115. |
| [15] | Singh B;Pal L .Development of sterculia gum based wound dressings for use in drug delivery[J].European Polymer Journal,2008(10):3222-3230. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%