PLGA(聚乳酸/乙醇酸共聚物)具有良好的生物降解性、相容性和降解产物无毒性等优点,且降解速率可由其分子量和共聚物组成比例来调控.本文采用静电纺丝法制备了以PLGA为壳层材料,聚乙烯基吡咯烷酮(PVP)、PLGA为内芯材料的同轴复合纤维,并研究了两种药物(5-氟尿嘧啶和番荔素)在纤维载体中的药物释放行为.在相同的释放环境中,与混纺纤维比较,同轴电纺得到负载了5-氟尿嘧啶的纤维在初期药物突释行为有所改善.同时,对于负载番荔素的同轴复合纤维,不同芯材样品能够表现出不同的释放行为.
参考文献
| [1] | Xie JW;Wang CH .Encapsulation of proteins in biodegradable polymeric microparticles using electrospray in the Taylor Cone-Jet mode[J].Biotechnology and Bioengineering,2007(5):1278-1290. |
| [2] | Loscertales IG;Barrero A;Guerrero I;Cortijo R;Marquez M .Micro/nano encapsutation via electrified coaxial liquid jets[J].Science,2002(5560):1695-1698. |
| [3] | SONG T;ZHANG YZ;ZHOU TJ .Fabrication of magnetic composite nanofibers of poly(ε-caprolactone) with FePt nanopaticles by coaxial electrospinning[J].Journal of Magnetism and Magnetic Materials,2006,303:286-289. |
| [4] | Jiang HL;Hu YQ;Li Y;Zhao PC;Zhu KJ;Chen WL .A facile technique to prepare biodegradable coaxial electrospun nanofibers for controlled release of bioactive agents[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2005(2/3):237-243. |
| [5] | Dan Li;Younan Xia .Direct Fabrication of Composite and Ceramic Hollow Nanofibers by Electrospinning[J].Nano letters,2004(5):933-938. |
| [6] | Sing Yian Chew;Jie Wen;Evelyn K.F.Yim;Kam W.Leong .Sustained Release of Proteins from Electrospun Biodegradable Fibers[J].Biomacromolecules,2005(4):2017-2024. |
| [7] | Cheryl L.Casper;Nori Yamaguchi;Kristi L.Kiick;John F.Rabolt .Functionalizing Electrospun Fibers with Biologically Relevant Macromolecules[J].Biomacromolecules,2005(4):1998-2007. |
| [8] | IC LIAO;SY CHEW;KW LEONG .Aligned core-shell nanofibers delivering bioactive proteins[J].Nanomedicine,2006,1:465-471. |
| [9] | Yiquan Wu;J. Andrew MacKay;Jonathan R. McDaniel .Fabrication of Elastin-Like Polypeptide Nanoparticles for Drug Delivery by Electrospraying[J].Biomacromolecules,2009(1):19-24. |
| [10] | YIXIANG XU;MILFORD HANNA;MACIEJ SKOTAK .Electrospray encapsulation of water-soluble protein with polylactide.I.Effects of formulations and process on morphology and particle size[J].Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres,2006(1):69-78. |
| [11] | YIXIANG XU;MILFORD A.HANNA .Electrosprayed bovine serum albumin-loaded tripolyphosphate cross-linked chitosan capsules:Synthesis and characterization[J].Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres,2007(2):143-151. |
| [12] | 赵敏丽,隋刚,杨小平,邓旭亮,胡晓阳.电纺丝PLLA/HA复合纤维支架的制备及体外降解性能研究[J].中国生物医学工程学报,2006(04):476-480. |
| [13] | Hakkarainen M.;Karlsson S.;Albertsson AC. .WEIGHT LOSSES AND MOLECULAR WEIGHT CHANGES CORRELATED WITH THE EVOLUTION OF HYDROXYACIDS IN SIMULATED IN VIVO DEGRADATION OF HOMO- AND COPOLYMERS OF PLA AND PGA[J].Polymer Degradation and Stability,1996(3):283-291. |
| [14] | Bashur CA;Dahlgren LA;Goldstein AS .Effect of fiber diameter and orientation on fibroblast morphology and proliferation on electrospun poly(D,L-lactic-co-glycolic acid) meshes[J].Biomaterials,2006(33):5681-5688. |
| [15] | Doshi J.;Reneker DH. .ELECTROSPINNING PROCESS AND APPLICATIONS OF ELECTROSPUN FIBERS[J].Journal of Electrostatics,1995(2/3):151-160. |
| [16] | Dong H;Nyame V;Macdiarmid AG;Jones WE .Polyaniline/poly(methyl methacrylate) coaxial fibers: The fabrication and effects of the solution properties on the morphology of electrospun core fibers[J].Journal of Polymer Science, Part B. Polymer Physics,2004(21):3934-3942. |
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