含咪唑功能基的手性羧酸酯和脂肪醇的合成

应用化学, 2006, 23(4): 362-365. doi: 10.3969/j.issn.1000-0518.2006.04.004

含咪唑功能基的手性羧酸酯和脂肪醇的合成

郭生金 ^1, , 罗奎 ^2, , 张仕勇 ^3, , 兰静波 ^4, , 谢如刚 ^5,

1.四川大学化学系,成都,610064;晋中学院生物科学与技术系,榆次

2.四川大学化学系,成都,610064

3.四川大学化学系,成都,610064

4.四川大学化学系,成都,610064

5.四川大学化学系,成都,610064

基金项目: 中国科学院资助项目(20472057)

关键词：天然氨基酸 , 手性咪唑羧酸酯 , 手性咪唑脂肪醇 , 合成

Syntheses of Chiral Alkanoates and Alkanols with Imidazole Ring as Functional Site

以天然的中性和酸性氨基酸为手性源,在碱性条件下与乙二醛、甲醛经过缩合反应生成了(S)-2-(咪唑-1-基)羧酸钠,再转化为甲酯,用硼氢化钠还原高产率地得到(S)-2-(咪唑-1-基)脂肪醇,其中3a～3g、4d～4e为新化合物.对所有化合物进行了结构表征.

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含咪唑功能基的手性羧酸酯和脂肪醇的合成

Syntheses of Chiral Alkanoates and Alkanols with Imidazole Ring as Functional Site

参考文献