Threo-N-benzoyl-3-phenylisoserine methyl ester was synthesized. Compound 3 was firstprepared from benzaldehyde and ethyl chloroacetate by Darzens condensation, then through am-monolysis, hydrolysis, acylation and methylation, rythro-N-benzoyl-3-phenylisoserine methyl esterwas obtained. The C-2 configuration inversion of the latter compound affords the title compound inyield of 42%. The compound was characterized by IR, 1H NMR and elemental analysis.
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