液相色谱-质谱在阿尔茨海默病研究中的应用

色谱 , 2013, 31(12): 1154-1160. doi: 10.3724/SP.J.1123.2013.07014

液相色谱-质谱在阿尔茨海默病研究中的应用

田士军 ^1, , 彭向雷 ^2, , 郑妍鹏 ^3, , 何金生 ^4, , 洪涛 ^5,

1.北京交通大学生命科学与生物工程研究院,北京,100044

2.北京交通大学生命科学与生物工程研究院,北京,100044

3.北京交通大学生命科学与生物工程研究院,北京,100044

4.北京交通大学生命科学与生物工程研究院,北京,100044

5.北京交通大学生命科学与生物工程研究院,北京100044;中国疾病预防控制中心病毒病预防控制所,北京100052

基金项目: 北京分子科学国家实验室开放课题基金中央高校基本科研业务费专项资金(2013JBM100,2012JBZ003) 国家自然科学基金项目(21205004)

关键词：液相色谱-质谱 , 阿尔茨海默病 , 临床化学 , 综述

Application of liquid chromatography-mass spectrometry in the research of Alzheimer's disease

Keywords： liquid chromatography-mass spectrometry (LC-MS) , Alzheimer' s disease (AD) , clinic chemistry , review

液相色谱-质谱联用(LC-MS)作为集高效分离与定性定量检测为一体的联用技术,近年来在化学、医学、药学和生物化学等领域获得了长足的发展,特别是由科研领域拓展到临床诊断,开启了疾病诊断技术的新篇章.阿尔茨海默病(Alzheimer's disease,AD),又称老年性痴呆症,是现代社会第四大致死疾病.随着我国人口的快速老龄化,重视对AD的防治是实现健康老龄化以及国民经济持续发展的重要保障之一本文对LC-MS的新进展进行了简介,并详细综述了近3年来其在AD研究中的应用,以期相关方法获得更好的理解与更多的关注.

参考文献

[1]	Zhou Y,WangY,Wang R,etal.JSep Sci,2008,31(13):2388
[2]	Himmelsbach M.J Chromatogr B,2012,883/884:3
[3]	Christin C,Bischoff R,Horvatovich P.Talanta,2011,83(4):1209
[4]	Colangelo C M,Chung L,Bruce C,et al.Methods,2013,61:287
[5]	Horvatovich P,Hoekman B,Govorukhina N,et al.J Sep Sci,2010,33(10):1421
[6]	Holcapek M,Jirasko R,Lisa M.J Chromatogr A,2012,1259:3
[7]	Chen C,Yan H,Shen B H,et al.Chinese Journal of Chromatography(陈聪,严慧,沈保华,等.色谱),2012,30(5):445
[8]	Yang Q,Shi X Z,Shan Y H,et al.Chinese Journal of Chromatography(杨芹,石先哲,单圆鸿,等.色谱),2013,30(9):876
[9]	Carvalho V M.J Chromatogr B,2012,883/884:50
[10]	Grebe S K,Singh RJ.Clin Biochem Rev,2011,32(1):5
[11]	Bozovic A,Kulasingam V.Clin Biochem,2013,46(6):444
[12]	Rauh M.J Chromatogr B,2012,883/884:59
[13]	Seger C.Wien Med Wochenschr,2012,162(21/22):499
[14]	Tamburri A,Dudilot A,Licea S,et al.PLoS One,2013,8(6):e65350
[15]	Friedman S D,Baker L D,Borson S,et al.JAMA Neurol,2013,70(7):883
[16]	Prince M,Bryce R,Fern C.World Alzheimer Report 2011:the Benefits of Early Diagnosis and Intervention.UK:Alzheimer' s Disease International (ADI),2011:9
[17]	Dillen L,Cools W,Vereyken L,et al.Bioanalysis,2011,3(1):45
[18]	Halim A,Brinkmalm G,Ruetschi U,et al.Proc Natl Acad Sci U S A,2011,108(29):11848
[19]	Craig-Schapiro R,Perrin R J,Roe C M,et al.Biol Psychiatry,2010,68(10):903
[20]	Oh J H,Pan S,Zhang J,et al.Rapid Commun Mass Spectrom,2010,24(4):403
[21]	Mattsson N,Zegers I,Andreasson U,et al.Biomark Med,2012,6(4):409
[22]	Sato Y,Suzuki I,Nakamura T,et al.J Lipid Res,2012,53(3):567
[23]	Zuliani G,Donnorso M P,Bosi C,et al.BMC Neurol,2011,11:121
[24]	Mielke M M,Haughey N J,Ratnam Bandaru V V,et al.Alzheimers Dement,2010,6(5):378
[25]	Kokjohn T A,Van Vickle G D,Maarouf C L,et al.Biochim Biophys Acta,2011,1812(11):1508
[26]	Shi M,Hwang H,Zhang J.Methods Mol Biol,2013,951:279
[27]	Butterfield D A,Owen J B.Proteomics Clin Appl,2011,5(1/2):50
[28]	Zhang K,Schrag M,Crofton A,et al.Proteomics,2012,12(8):1261
[29]	Donovan L E,Higginbotham L,Dammer E B,et al.Proteomics Clin Appl,2012,6(3/4):201
[30]	Lynn B C,Wang J,Markesbery W R,et al.J Alzheimers Dis,2010,19(1):325
[31]	Ringman J M,Schulman H,Becker C,et al.Arch Neurol,2012,69(1):96
[32]	Jahn H,Wittke S,Zurbig P,et al.PLoS One,2011,6(10):e26540
[33]	Portelius E,Brinkmalm G,Tran A,et al.Exp Neurol,2010,223(2):351
[34]	Vafadar-Isfahani B,Ball G,Coveney C,et al.J Alzheimers Dis,2012,28(3):625
[35]	Yang M H,Yang Y H,Lu C Y,et al.J Proteomics,2012,75(12):3617
[36]	Ijsselstijn L,Dekker L J,Stingl C,et al.J Proteome Res,2011,10(11):4902
[37]	Nakamura T,Myint K T,OdaY.J Proteome Res,2010,9(3):1385
[38]	Thomas S N,Cripps D,Yang A J.Methods Mol Biol,2009,566:109
[39]	Taki T.Biol Pharm Bull,2012,35(10):1642
[40]	Hejazi L,Wong J W,Cheng D,et al.Biochem J,2011,438(1):165
[41]	ChanRB,OliveiraT G,Cortes E P,et al.J Biol Chem,2012,287(4):2678
[42]	Jung K M,Astarita G,Yasar S,et al.Neurobiol Aging,2012,33(8):1522
[43]	Wood P L,Mankidy R,Ritchie S,et al.J Psychiatry Neurosci,2010,35(1):59
[44]	Kosicek M,Kirsch S,Bene R,et al.Anal Bioanal Chem,2010,398(7/8):2929
[45]	Sato Y,Nakamura T,Aoshima K,et al.Anal Chem,2010,82(23):9858
[46]	Czech C,Berndt P,Busch K,et al.PLoS One,2012,7(2):e31501
[47]	Li N J,Liu W T,LiW,etal.Clin Biochem,2010,43(12):992
[48]	Mishur R J,Rea S L.Mass Spectrom Rev,2012,31 (1):70
[49]	Chang S H,Jung I S,Han G Y,et al.Biochem Biophys Res Commun,2013,430(2):670
[50]	Thomas S N,Funk K E,Wan Y,et al.Acta Neuropathol,2012,123(1):105
[51]	Ridnour L A,Dhanapal S,Hoos M,et al.J Neurochem,2012,123(5):736
[52]	Cui J,Wang Y,Dong Q,et al.J Neurosci,2011,31(45):16227
[53]	Ma G,Huang F,Pu X,et al.Chemistry,2011,17(41):11657
[54]	Herskowitz J H,Seyfried N T,Gearing M,et al.J Biol Chem,2011,286(8):6117
[55]	Teranishi Y,Hur J Y,Welander H,et al.J Cell Mol Med,2010,14(11):2675
[56]	Oikawa N,Goto M,Ikeda K,et al.Neurosci Lett,2012,525 (1):49
[57]	Skorobogatko Y V,Deuso J,Adolf-Bryfogle J,et al.Amino Acids,2011,40(3):765
[58]	Naylor J C,Kilts J D,Hulette C M,et al.Biochim Biophys Acta,2010,1801(8):951
[59]	Panchal M,Loeper J,Cossec J C,et al.J Lipid Res,2010,51(3):598
[60]	Peng L,Jiang T,Rong Z,et al.J Chromatogr B,2011,879:3927
[61]	Ge X X,Wang X L,Jiang P,et al.J Chromatogr B,2012,881/882:126
[62]	Portelius E,Zhang B,Gustavsson M K,et al.Neurodegener Dis,2009,6(5/6):258
[63]	Overk C R,Borgia J A,Mufson E J.J Neurosci Methods,2011,195(2):194
[64]	Overk C R,LuPY,Wang Y T,etal.Neurobiol Dis,2012,45(1):479
[65]	Alonso E,Otero P,Vale C,et al.Curr Alzheimer Res,2013,10(3):279

上一张下一张

计量

下载量()
访问量()

作者相关

文章评分

您的评分：
1

0%
2

0%
3

0%
4

0%
5

0%

材料期刊网