三环己基锡8-羟基喹啉配合物的微波辅助合成、结构表征、热稳定性和体外抗癌活性

应用化学, 2014, 31(8): 937-942. doi: 10.3724/SP.J.1095.2014.30495

三环己基锡8-羟基喹啉配合物的微波辅助合成、结构表征、热稳定性和体外抗癌活性

庾江喜 ^1, , 冯泳兰 ^2, , 邝代治 ^3, , 张复兴 ^4, , 蒋伍玖 ^5, , 朱小明 ^6,

基金项目: 湖南省科技计划(2013TZ2025,2014NK3086) 湖南省高校创新平台开放基金(13K105) 衡阳市科技计划(2011KG56,2012KJ30) Scientific & Technological Projects of Hengyang City,China(2011KG56,2012KJ30) 湖南省自然科学基金(13JJ3112) 衡阳师范学院协同创新中心培育项目(12XT02) the Open Fund Based on Innovation Platform of Hunan Universities,China(13K105) 衡阳师范学院青年骨干教师培养计划(2012)资助 Supported by Hunan Provincial Natural Science Foundation of China(13JJ3112) the Youth Backbone Teacher Training Program of Hengyang Normal University,China(2012) Scientific Research Fund of Hunan Provincial Education Department(12C0537) Cultivation Projects Based on Collaborative Innovation Center of Hengyang Normal University,China(12XT02) Scientific & Technological Projects of Hunan Province,China(2013TZ2025,2014NK3086) 教育厅一般项目(12C0537)

关键词：三环己基锡8-羟基喹啉配合物 , 微波辅助合成 , 晶体结构 , 抗癌活性

Microwave Assisted Synthesis, Structural Characterization, Thermal Stability and in vitro Anticancer Activity of Tricyclohexyltin 8-Quinolinoxide

Keywords： tricyclohexyltin 8-quinolinol complex , microwave assisted synthesis , crystal structure , anticancer activity

微波辐射下,8-羟基喹啉与三环己基氢氧化锡反应,合成了三环己基锡配合物Cy3SnOC9NH6(Cy为环己基).通过UV、IR、1H和13C NMR、元素分析及X射线单晶衍射等技术手段表征结构.实验结果表明,该配合物属三斜晶系,空间群P1,晶体学参数:a=0.99530(5) nm,b=1.01129(5) nm,c =2.58327(13) nm,α=89.1880(10)°,β=86.6290(10)°,γ=81.2490(10)°,Z=4,V=2.5654(2)nm3,Dc=1.326 Mg/m3,μ(Mogα)=1.013mm-1,F(000) =1064,R1=0.0447,wR2 =0.0891.配合物在200℃以下稳定,对人体的癌细胞Colo205、HepG2、MCF-7和NCI-H460增殖均有较强的抑制作用.

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