设计合成了9种未见文献报道的双三唑席夫碱哒嗪酮化合物.用1H NMR、13C NMR、IR及元素分析表征结构.生物活性初步结果表明,在500 mg/L浓度下部分化合物对黄瓜花叶病毒(CMV)、小麦赤霉病菌(G.zeae)、辣椒枯萎病菌(F.oxysporum)和苹果腐烂病菌(C.mandshurica)有一定抑制作用.
参考文献
| [1] | Heinisch G,Kopelent F H.Pharmacologically Active Pyridazine Derivatives[J].Prog Med Chem,1990,27:1-49. |
| [2] | SHA Jiajun,ZHANG Minheng,JIANG Yajun.The Handbook of New Breed Pesticide of Overseas[M].Beijing:Chemical Industry Press,1993,10:130(in Chinese).沙家骏,张敏恒,姜雅君.国外新农药品种手册[M].北京:化学工业出版社,1993,10:130. |
| [3] | LI Hongsen,LING Yun,GUO Yulai,et al.Study on the Synthesis and Bioactivity of Pyridazinone Derivatives[J].Chinese J Org Chem,2005,25(2):204-207(in Chinese).李洪森,凌云,郭钰来,等.哒嗪酮衍生物的合成和生物活性研究[J].有机化学,2005,25(2):204-207. |
| [4] | HU Guoqiang,YAO Sumei,LI Sheng,et al.Synthesis and Antibacterial Activity of s-Triazole Salicylidene-amino Schiffbases Containing Oxadiazole-Substituted Oxime-ether[J].Chinese J Org Chem,2007,27(5):636-639(in Chinese).胡国强,姚素梅,李省,等.含(口恶)二唑肟醚取代的均三唑水杨醛席夫碱的合成及抗菌活性[J].有机化学,2007,27(5):636-639. |
| [5] | CHEN Wenbin,JIN Guiyu.Studies on Synthesis and Biological Activities of Novel Triazole Compounds Containing Sulfur[J].Chem J Chinese Univ,2001,22(7):1147-1151(in Chinese).陈文彬,金桂玉.新型含硫三唑类化合物的合成及生物活性研究[J].高等学校化学宇报,2001,22(7):1147-1151. |
| [6] | John H,Witkowski R,Robert W,et al.In Vitro Effect of 1-β-D-Ribofuranosyl-1,2,4-Triazole-3-Carboxamide(Virazole,ICN 1229) on Deoxyribonucleic Acid and Ribanucleic Acid Viruses[J].J Med Chem,1973,3(2):235-241. |
| [7] | LU Yanchang,LIU Jianbing,LIANG Hua,et al.Synthesis and Biological Activities of 1H-1,2,4-Triazole Derivatives Containing Aryloxyacetate Unit[J].Chinese J Org Chem,2006,26(11):1571-1575(in Chinese).卢彦昌,刘建兵,梁华,等.新型含芳氧乙酸酯基三唑酮类化合物的合成及生物活性研究[J].有机化学,2006,26(11):1571-1575. |
| [8] | Ren S,Wang R,Komatsu K,et al.Synthesis,Biological Evaluation,and Quantitative Structure Activity Relationship Analysis of New Schiff Bases of Hydroxysemicarbazide as Potential Antitumor Agents[J].J Med Chem,2002,45(11):410-419. |
| [9] | Karthikeyan M S,Prasad D J,Poojary B,et al.Synthesis and Biological Activity of Schiff and Mannich Bases Bearing 2,4-Dichloro-5-fluorophenyl Moiety[J].Bioorg Med Chem,2006,14(22):7482-7489. |
| [10] | Vicini P,Geronikaki A,Incerti M,et al.Synthesis and Biological Evaluation of Benzo[d]isothiazole,Benzothiazole and Thiazole Schiff Bases[J].Bioorg Med Chem,2003,11(22):4785-4789. |
| [11] | Shivarama H B,Akberali P M,Shivananda M K.Studies on Nitrophenylfuran Derivatives:Part Ⅻ.Synthesis,Characterization,Antibacterial and Antiviral Activities of Some Nitrophenylfurfurylidene-1,2,4-tria-zolo[3,4-b]-1,3,4-thiadiazines[J].H Farmaco,2001,56(12):919-927. |
| [12] | Bagiballi G B,Avaji P G,Patil S A,et al.Synthesis,Spectral Characterization,In vitro Antibacterial,Antifungal and Cytotoxic Activities of Co(Ⅱ),Ni(Ⅱ) and Cu(Ⅱ) Complexes with 1,2,4-Triazole Schiff Bases[J].Eur J Med Chem,2008,43(12):2639-2649. |
| [13] | Ashok M,Holla B S,Poojary B.Convenient One Pot Synthesis and Antimicrobial Evaluation of Some New Mannich Bases Carrying 4-Methylthiobenzyl Moiety[J].Eur J Med Chem,2007,42(8):1095-1101. |
| [14] | Holla S B,Veerendra B,Shivananda M K,et al.Synthesis Characterization and Anticancer Activity Studies on Some Mannich Bases Derived from 1,2,4-Triazoles[J].Eur J Med Chem,2003,38(8):759-767. |
| [15] | SUN Xiaohong,TAO Yan,LIU Yuanfa,et al.Synthesis and Biological Activities of N-(5-Alkyl-2,4-dihydro-3-thioxo-1,2,4-triazol-4-yl) Schiff Bases[J].Chinese J Org Chem,2008,28(1):155-159(in Chinese).孙晓红,陶燕,刘源发,等.烷基取代三唑硫酮席夫碱的合成和生物活性研究[J].有机化学,2008,28(1):155-159. |
| [16] | HU Guoqiang,XIE Songqiang,DU Gangjun,et al.Syntheses and Antibacterial Activities of Bis(amino-triazole sulfurether)and Their Piperonal Sohiff's Base Derivatives[J].Chinese J Appl Chem,2006,23(3):273-277(in Chinese).胡国强,谢松强,杜刚军,等.双氨基三唑硫醚及其与胡椒醛席夫碱的合成及抗菌活性[J].应用化学,2006,23(3):273-277. |
| [17] | Chen C J,song B A,Yang S,et al.Synthesis and Antifungal Activities of 5-(3,4,5-Trimethoxyphenyl)-2-sulfonyl-1,3,4-thiadiasole and 5-(3,4,5-Trimethoxyphenyl)-2-sulfonyl-1,3,4-oxadiazole Derivatives[J].Bioorg Med Chem,2007,15(12):3981-3989. |
| [18] | LI Qianzhu,SONG Baoan,CHEN Jiang,et al.Preparation and Application of 3-Substitued-2-substitued Phenyl-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole Derivatives:CN,200610050996.2[P],2006-08-30(in Chinese).李黔柱,宋宝安,陈江,等.3-取代-2-芳基取代-5-(3,4,5-三烷氧基苯基)-1,3,4-(口恶)二唑衍生物及制备方法和用途.中国200610050996.2[P],2006-08-30. |
| [19] | LI Qianzhu,SONG Baoan,CAI Xuejian,et al.Synthesis and Bioactivities of Novel N-1,2,4-Triazole Moieties Imines Containing Fluorocinnamylidene[J].Chinese J Org Chem,2010,30(4):569-575(in Chinese).李黔柱,宋宝安,蔡学建,等.N-(1,2,4-三唑)含氟肉桂醛亚胺的合成及生物活性[J].有机化学,2010,30(4):569-575. |
| [20] | TAN Xiaohua.Study on the Synthesis of Nitrogen Heterocyclic Pyridazinones[D].Changsha:Hunan University,2003(in Chinese).谭小华.导入含氮杂环的哒嗪酮衍生物的合成研究[D].长沙:湖南大学,2003. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%