用微热量热仪测量紫杉醇在二甲亚砜中的溶解焓.得到了微分溶解热(△difHm)和积分溶解热(△solHm),建立了热量与溶质的量之间的关系式.并得到了紫杉醇在二甲亚砜中溶解过程的动力学方程:da/dt=2.92×10-4×(1-a)1.00,半衰期t1/2=50.43 min,△solHm=32.67 kJ/mol以及△solSm=-204.93 J/(mol·K).结果表明,利用微热量热法可以为药物半衰期的测定提供一种简便的方法,并可为紫杉醇的临床应用提供理论参考.
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