DNA折纸术是近年来提出的一种全新的DNA自组装的方法,是DNA纳米技术与DNA自组装领域的一个重大进展.与传统的DNA自组装技术不同,DNA折纸术通过将一条长的DNA单链(通常为基因组DNA)与一系列经过设计的短DNA片段进行碱基互补,能够可控地构造出高度复杂的纳米图案或结构,在新兴的纳米领域中具有广泛的潜在应用.本文在介绍DNA折纸术相关原理的基础上,就DNA折纸术的起源、发展及其在DNA芯片、纳米元件与材料等领域的潜在应用进行了概述,探讨了DNA折纸术未来可能的发展方向.
DNA origami is a new DNA self-assembly method proposed recently and is a major innovation in the field of DNA nanotechnology and self-assembly. Compared to traditional DNA self-assembly, DNA origami uses a long single-stranded genomic DNA with a series of short complementary single-strands DNA, and it can construct more complex and more controllable nanopatterns or structures and possess a wide range of potential application in the emerging field of nanotechnology. The authors briefly introduced the principles of DNA origami, then reviewed the origin and development of DNA origami and its potential application in the field of DNA chip, nanocomponents and nanomaterials. In the end we discussed the future directions of such technology.
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