应用纤维素三(3,5-二甲基苯基氨基甲酸酯)(CDMPC)手性固定相对2种羰基钌金属簇合物进行了拆分,通过流动相组成、流速和样品溶剂等条件对拆分影响的考察对拆分条件进行了优化.实验结果表明,簇合物1和簇合物2分别在含乙醇(V(hexane): V(ethanol)=95: 5)和异丙醇(V(hexane): V(2-propanol)=90: 10)的流动相中得到了较好的拆分,将样品溶解在和流动相组成相近的溶剂中更利于簇合物拆分,簇合物配体结构对簇合物在固定相上的保留和拆分有重要的影响.在优化条件下,2种金属簇合物分离度均达到1.5以上.
Two carbonyl triruthenium metal clusters were separated with cellulose tris(3,5-dimethylphenyl-carbamate)(CDMPC) as chiral stationary phase. The effects of the optimal conditions were determined according to the effects of the mobile phase composition,the flow rate of the mobile phase and the solvents of the samples etc on the chiral separation of the metal clusters. The results show that good chiral separations of cluster 1 and cluster 2 were obtained,respectively,using the mobile phase with ethanol(V(hexane):V(ethanol)=95: 5) and 2-propanol(V(hexane): V(2-propanol)=90: 10). The solvents of the samples with similar composition to that of the mobile phase were beneficial to the chiral separation of the clusters. The structures of the metal-chelated ligand exerted an important influence on the retention and chiral separation of the metal clusters. The R_s of the clusters were above 1.5 under the optimal conditions.
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