在温和条件下,Zn(OTf)_2能有效催化氯化苄对对氯苯酚的C-苄基化反应,选择性合成杀菌剂2-苄基-4-氯苯酚(BCP),合成的优化条件为n(对氯苯酚):n(氯化苄)=1.2:1,催化剂Zn(OTf)_2对氯化苄摩尔分数为5%,60 ℃下反应6 h,用硝基甲烷为溶剂,氯化苄转化率和产物BCP的产率分别＞99%和94%.
C-Benzylation of 4-chlorophenol(BCP) was selectively perpared via the catalysis of Zn(OTf)_2 under mild conditions with an excellent yield. The optimum reaction conditions included that the molar ratio of the reactants (4-chlorophol:benzyl chloride) was 1.2:1,5% Zn(OTf)_2(molar ratio),and 6 h agitation at 60 ℃ in nitromethane. The conversion of 4-chlorophenol and selectivity of BCP were ＞99% and 94%,respectively under the conditions.
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