欢迎登录材料期刊网

材料期刊网

高级检索

生物材料的生物相容性是生物材料研究领域的关键科学问题.分子生物学技术的发展使生物材料的生物相容性评价从动物水平和细胞水平深入到分子水平.生物组学技术的发展为高通量进行生物材料分子生物相容性评价、阐明生物材料与生物体的相互作用机理提供了有效的手段.本文综述了生物材料生物相容性研究现状及基因组学、蛋白质组学技术在生物材料生物相容性研究中的应用.

参考文献

[1] Hegyeli R J.Limitations of current techniques for assessing biohazards and biocompatibility of new candidate materials-orpl.Abstracts of papers of the American Chemical Society,1970,1.
[2] Homsy C A,Ansevin KD,Obannon W,et al.Rapid in-vitro screening of polymers for biocompatibility.J.Macromol.Sci.A,1970,4(3):615.
[3] 顾汉卿,徐国风.生物医学材料学.天津:天津科技翻译出版公司,1993:92.
[4] Williams D F.Definitions in biomaterials.Progress in biomedical engineering,Amsterdam:Elsevier,1987:72.
[5] Rickert D,Lendlein A,Peters I,et al.Biocompatibility testing of novel multifunctional polymeric biomaterials for tissue engineering applications in head and neck surgery:an overview.Eur.Arch.Otorhinolaryngol.,2006,263(3):215-222.
[6] Williams D F.On the mechanisms of biocompatibility.Biomaterials,2008,29(20):2941-2953.
[7] Lü XY,Bao X,Huang Y,et al.Mechanisms of cytotoxicity of nickel ions based on gene expression profiles.Biomaterials,2009,30(2):141-148.
[8] Chou L S,Firth J D,Uitto V J,et al.Substratum surface topography alters cell shape and regulates fibronectin mRNA level,mRNA stability,secretion and assembly in human fibroblasts.J.Cell Sci.,1995,108(4):1563-1573.
[9] Chou L S,Firth J D,Nathanson D,et al.Effects of titanium on transcriptional and post-transcriptional regulation of fibronectin inhuman fibroblasts.J.Biomed.Mater.Res.,1996,31(2):209-217.
[10] Chou L S,Firth J D,Uitto V J,et al.Effects of titanium substratum and grooved surface topograhy on metalloproteinase-2 expression in human fibroblasts.J.Biomed.Mater.Res.,1998,39(3):437-445.
[11] Ripamonti U,Crooks J,Khoah L,et al.The induction of bone formation by coral-derived calcium carbonate/hydroxyapatite constructs.Biomaterials,2009,30(7):1428-1439.
[12] Park S H,Gil E S,Shi H,et al.Relationships between degradability of silk scaffolds and osteogenesis.Biomaterials,2010,31(24):6162-6172.
[13] Im D D,Kruger E A,Huang W B R,et al.Extracellular-signal-related kinase 1/2 is responsible for inhibition of osteogenesis in three-dimensional cultured MC3T3-E1 cells.Tissue Eng.A,2010,16(11):3485-3494.
[14] Brown P O,Botstein D.Exploring the new world of the genome with DNA microarrays.Nat.Genet.(Suppl),1999,21(1):33-37.
[15] Peng J,Gygi S P.Proteomics:the move to mixtures.J.Mass Spectrom,.2001,36(10):1083-1091.
[16] Yuan Q,Zhao F K.New frontiers in the proteome research:quantitative proteomics.Acta Biochimica Et Biophysica Sinica.,2001,33(5):477-482.
[17] Mueller P P,May T,Perz A,et al.Control of muscle cell proliferation by ferrous iron.Biomaterials,2006,27(10):2193-2200.
[18] Lü X Y,Lu H Q,Zhao L F,et al.Genome-wide pathways analysis of nickel ion-induced differential genes expression in fibroblasts.Biomaterials,2010,31(8):1965-1973.
[19] Kasprzak K S,Sunderman F W,Salnikowa K.Nickel carcinogenesis.Mutat.Res.-Fund.Mol.M.,2003,533(1/2):67-97.
[20] Zhao L F,Hong Y,Yang D Y,et al.The underlying biological mechanisms of biocompatibility differences between bare and TiN-coated NiTi alloys.Biomed.Mater,2011,6(2):025012-1-12.
[21] Hong Y,Zhao L F,Yang D Y,et al.Analyses of differentially expressed genes in human cell in response to uncoated and Ti-coated NiTi alloys.The 2011 International Conference on Information Science and Technology (ICIST 2011),Nanjing,2011:1377-1381.
[22] Yang D Y,Hong Y,Zhao L F,et al.Proteomic analysis of human endothelial cells in response to bare and titanium nitride-coated NiTi alloys.3rd Chinese-Europe Symposium on Biomaterials in Regenerative Medicine,Nanjing,2011:159.
[23] Lee H,Ko S H.Microarray analysis of MC3T3-E1 osteoblastic cell response to machined titanium surface and resorbable blast material titanium surface.Bone,2011,48(Suppl 2):S111.
[24] Sollazzo V,Palmieri A,Pezzetti F,et al.Genetic effect of zirconium oxide coating on osteoblast-like cells.J.Biomed.Mater Res.B,2008,84B(2):550-558.
[25] Derhami K,Zheng J,Li L,et al.Proteomic analysis of human skin fibroblasts grown on titanium:novel approach to study molecular biocompatibility.J.Biomed Mater Bes.,2001,56(2):234-244.
[26] Leven R M,Virdi A S,Sumner D R.Patterns of gene expression in rat bone marrow stromal cells cultured on titanium alloy discs of different roughness.J.Biomed.Mater Res.A,2004,70A(3):391-401.
[27] Zhao M,An M,Wang Q,et al.Quantitative proteomic analysis of human osteoblast-like MG-63 cells in response to bioinert implant material titanium and polyetheretherketone,J.Proteomics,2012,75(12):3560-3573.
[28] Xie J,Baumann M J,McCabe L R.Osteoblasts respond to hydroxyapatite surfaces with immediate changes in gene expression.J.Biomed.Mater Res.,2004,71A(1):108-117.
[29] Song J H,Kim J H,Park S,et al.Signaling responses of osteoblast cells to hydroxyapatite:the activation of ERK and SOX9.J.Bone Miner.Metab.,2008,26(2):138-142.
[30] Xu J L,Khor K A,Sui J J,et al.Comparative proteomics profile of osteoblasts cultured on dissimilar hydroxyapatite biomatefials:an iTRAQ-coupled 2-D LC-MS/MS analysis.Proteomics,2008,8(20):4249-4258.
[31] Xu J L,Khor K A,Sui J J,et al.Protein expression profiles in osteoblasts in response to differentially shaped hydroxyrapatite nanoparticles.Biomaterials,2009,30(29):5385-5391.
[32] 王健丹.基于基因表达谱芯片技术的天然羟基磷灰石成骨诱导机理研究.南京:东南大学硕士论文,2010.
[33] Wang J D,Lü X Y,Li B,et al.Mechanism Study on Osteoinductive Property of Natural Hydroxyapatite to Bone Marrow Mesenchymal Stem Cell.National Conference on Biomaterials,Chengdu,2010.
[34] Zhang Z W,Lü X Y,Wang J D.Pilot Study of Osteoinduction mechanism of Natural Hydroxyapatite.9th World Biomaterials Congress,Chengdu,2012.
[35] Carinci F,Piattelli A,Degidi M,et al.Genetic effects of anorganic bovine bone (Bio-Oss(R)) on osteoblast-like MG63 cells.Arch.Oral Biol.,2006,51(2):154-163.
[36] Zhang L L,Hanagata N,Maeda M,et al.Porous hydroxyapatite and biphasic calcium phosphate ceramics promote ectopic osteoblast differentiation from mesenchymal stem cells.Sci.Tech.Adv.Mater,2009,10(2):025003.
[37] Khan J A,Pillai B,Das T K,et al.Molecular effects of uptake of gold nanoparticles in HeLa cells.ChemBioChem,2007,8(11):1237-1240.
[38] Kawata K,Osawa M,Okabe S.In vitro toxicity of silver nanoparticles at noncytotoxic doses to HepG2 human hepatoma cells.Environ.Sci.Technol.,2009,43(15):6046-6051.
[39] Kirn E,Chu Y C,Han J Y,et al.Proteomic analysis of silver nanoparticle toxicity in rat.Toxicol.Environ.Health.Sci.,2010,2(4):251-262.
[40] Yang Y M,Qu Y H,L(U) X Y.Global gene expression analysis of the effects of gold nanoparticles on human dermal fibroblasts.J.Biomed Nanotechnol.,2010,6(3):234-246.
[41] Ma J W,Lü X Y,Huang Y.Genomic analysis of cytotoxicity response to nanosilver in human dermal fibroblasts.J.Biomed Nanotechnol.,2011,7(2):263-275.
[42] Lv X Y,Qu Y H,Yang Y M,etal.Proteomic analysis of molecular mechanism of interactions between gold nanoparticles and human dermal fibroblasts-fetal.Journal of Functional Materials,2011,42(6):1016-1020.
[43] Li X Y,Huang Y,Ma J W.Mechanism study of cytotoxicity of silver nanoparticles based on biomics methods.Chinese Journal of Dental Materials and Devices,2010,19(4):179-182.
[44] Cui D X,Tian F R,Ozkan C S,et al.Effect of single wall carbon nanotubes on human HEK293 cells.Toxicol.Lett.,2005,155(1):73-85.
[45] Ding L G,Stilwell J,Zhang T T,et al.Molecular characterization of the cytotoxic mechanism of multiwall carbon nanotubes and nano-onions on human skin fibroblast.Nano Lett.,2005,5(12):2448-2464.
[46] Peng L,Barczak A J,Barbeau R A,et al.Whole genome expression analysis reveals differential effects of TiO2 nanotubes on vascular cells.Nano Left.,2010,10(1):143-148.
[47] Chew S Y,Mi R,Hoke A,et al.The effect of the alignment of electrospun fibrous scaffolds on Schwann cell maturation.Biomaterials,2008,29(6):653-661.
[48] Agudelo-Garcia P A,De Jesus J K,Williams S P,et al.Glioma cell migration on three-dimensional nanofiber scaffolds is regulated by substrate topography and abolished by inhibition of STAT3 signaling.Neoplasia,2011,13(9):831-840.
[49] He W,Yong T,Ma Z W,et al.Biodegradable polymer nanofiber mesh to maintain functions of endothelial cells.7issue Eng.,2006,12(9):2457-2466.
[50] Yu Y D,Lü X Y.Integrin roles in Aligned Nanofiber influence PC12 Cell Differentiation.9th World Biomaterials Congress,Chengdu,2012.
[51] Dinnes D L M,Marcal H,Mahler S M,et al.Material surfaces affect the protein expression patterns of human macrophages:a proteomics approach.J.Biomed.Mater.Res.A,2007,80A(4):895-908.
[52] Rahman M A,Kumar S G,Kim S W,et al.Proteomic analysis for inhibitory effect of chitosan oligosaccharides on 3T3-L1 adipocyte differentiation.Proteomics,2008,8(3):569-581.
[53] Jaworski J,Klapperich C M.Fibroblast remodeling activity at two-and three-dimensional collagen-glycosaminoglycan interfaces.Biomaterials,2006,27(23):4212-4220.
[54] Klapperich C M,Bertozzi C R.Global gene expression of cells attached to a tissue engineering scaffold.Biomaterials,2004,25(25):5631-5641.
[55] Li G N,Livi L L,Gourd C M,et al.Genomic and morphological changes of neuroblastoma cells in response to three-dimensional matrices,Tissue Eng.,2007,13(5):1035-1047.
[56] Xue M.Biological evaluation of medical devices-test animal welfare requirements.Chinese Journal of Dental Materials and Devices,2007,16(3):117-124.
[57] Johansson H,Lindstedt M,Albrekt A S,et al.A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro altemative to animal tests.BMC Genomics,2011,12:399-1-19.
上一张 下一张
上一张 下一张
计量
  • 下载量()
  • 访问量()
文章评分
  • 您的评分:
  • 1
    0%
  • 2
    0%
  • 3
    0%
  • 4
    0%
  • 5
    0%