采用物理共混法(PB)、化学共沉积法(CC)和仿生浸泡法(BI)合成了多壁碳纳米管/羟基磷灰石复合粉(MWNTs/HA),并将其作为磷酸钙骨水泥(CPC)的固相粉末之一,分别制备了相应的CPC样品.由于MWNTs对液相中水分子的吸附、毛细管作用以及表面存在较多的亲水基团,使得含有MWNTs的CPC样品的亲水性得以提高,且初凝时间和终凝时间都有所缩短,但仍满足临床应用的要求.由于CPC中的MWNTs/HA复合粉末的合成方式不同,使之对CPC的抗压性能、CPC中HA的结晶性、微观形貌影响均较大,但并不影响CPC的晶相组成.其中PB法所合成的MWNTs/HA复合粉末能促进CPC中纳米级HA晶体的转化和生长,使针状HA含量的表现为最高,且抗压力学性能为最好,其抗压强度和弹性模量分别较空白CPC提高了48.23%和41.87%.
参考文献
[1] | Theiss F,Apelt D,Brand B,et al.Biocompatibility and resorption of a brushite calcium phosphate cement.Biomaterials,2005,26(21):4383-4394. |
[2] | van den Vreken N M F,Pieters I Y,Declercq H A,et al.Characterization of calcium phosphate cements modified by addition of amorphous calcium phosphate.Acta Biomaterialia,2010,6(2):617-625. |
[3] | Ambard A J,Mueninghoff L.Calcium phosphate cement:review of mechanical and biological properties.Journal of Prosthodontics,2006,15(5):321-328. |
[4] | Muller F A,Gbureck U,Kasuga T,et al.Whisker-reinforced calcium phosphate cements.Journal of the American Ceramic Society,2007,90(11):3694-3697. |
[5] | Dos Santos L A,De Oliveira L C,da Silva Rigo E C,et al.Fiber reinforced calcium phosphate cement.Artificial Organs,2000,24(3):212-216. |
[6] | Kikuchi M,Suetsugu Y,Tanaka J,et al.Preparation and mechanical properties of calcium phosphate/copoly-L-lactide composites.Journal of Materials Science:Materials in Medicine,1997,8(6):361-364. |
[7] | Iijima S.Helical microtubules of graphitic carbon.Nature,1991,354(6348):56-58. |
[8] | Li C,Chou T W.Elastic moduli of multi-walled carbon nanotubes and the effect of van der Waals forces.Composites Science and Technology,2003,63(11):1517-1524. |
[9] | Chlopek J,Czajkowska B,Szaraniec B,et al.In vitro studies of carbon nanotubes biocompatibility.Carbon,2006,44(6):1106-1111. |
[10] | Huczko A,Lange H.Carbon nanotubes:experimental evidence for a null risk of skin irritation and allergy.Fullerene Science and Technology,2001,9(2):247-250. |
[11] | Wang X,Ye J,Wang Y,etal.Reinforcement of calcium phosphate cement by bio-mineralized carbon nanotube.Journal of the American Ceramic Society,2007,90(3):962-964. |
[12] | Chew K K,Low K L,Sharif Zein S H,et al.Reinforcement of calcium phosphate cement with multi-walled carbon nanotubes and bovine serum albumin for injectable bone substitute applications.Journal of the Mechanical Behavior of Biomedical Materials,2011,4(3):331-339. |
[13] | Rosca I D,Watari F,Uo M,et al.Oxidation of multiwalled carbon nanotubes by nitric acid.Carbon,2005,43(15):3124-3131. |
[14] | Aryal S,Bhattarai S R,Remant B,et al.Carbon nanotubes assisted biomimetic synthesis of hydroxyapatite from simulated body fluid.Materials Science and Engineering:A,2006,426(1/2):202-207. |
[15] | ASTM-Standard C266-99.Standard Test Method for Time of Setting of Hydraulic Cement Paste by Gilmore Needles.ASTM International,2002. |
[16] | Khairoun I,Boltong M,Driessens F,et al.Effect of calcium carbonate on clinical compliance of apatitic calcium phosphate bone cement.Journal of Biomedical Materials Research,1997,38(4):356-360. |
[17] | WANG Wan-Lu,WU Zi-Hua,LIAO Ke-Jun,et al.Enhanced humidity effect of carbon nanotubes by chemical modified.Micronanoelectronic Technology,2003,40(7):517-519. |
[18] | Thomas W E.Wetting,filling and decorating carbon nanotubes.Journal of Physics and Chemistry of Solids,1996,57(6/7/8):951-955. |
[19] | Aryal S,Bahadur K,Dharmaraj N,et al.Synthesis and characterization of hydroxyapatite using carbon nanotubes as a nano-matrix.Scripta Materialia,2006,54(2):131-135. |
[20] | Liao S,Xu (,Wang W,et al.Self-assembly of nano-hydroxyapatite on multi-walled carbon nanotubes.Acta Biomaterialia,2007,3(5):669--675. |
[21] | Weiner S,Addadi L.Design strategies in mineralized biological materials.J.Mater.Chem.,1997,7(5):689-702. |
[22] | Ishikawa K,Ducheyne P,Radin S.Determination of the Ca/P ratio in calcium-deficient hydroxyapatite using X-ray diffraction analysis.Journal of Materials Science Materials in Medicine,1993,4(2):165-168. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分:
-
10%
-
20%
-
30%
-
40%
-
50%