采用共混-真空烧结方法制备了一系列超顺磁性磷酸钙复合支架,通过SEM、EDS、XRD和VSM等手段对所制备的材料性能进行表征,并考察了其在水中的稳定性以及Ros17/2.8细胞在材料表面的黏附生长情况.结果表明:该方法所制备的超顺磁性复合支架具有多级连通孔结构,磁性纳米颗粒在基体中分布均匀,结合牢固且复合量精确可控,在水中具有良好的稳定性.真空烧结避免了磁性纳米颗粒在烧结过程中发生氧化和相变,使复合支架继续保持超顺磁性并具有良好的磁性能,且该磁性支架有利于细胞的黏附和生长,具有较好的生物相容性,在组织工程中有潜在的应用前景.
参考文献
| [1] | Bassett C A L,Schink-Ascani M,Lewis S M.Effects of pulsed electromagnetic fields on steinberg ratings of femoral head osteonecrosis.Clin.Orthop.Relat.Res.,1989,185(246):172-185. |
| [2] | Santini M T,Rainaldi G,Ferrante A,et al.Effects of a 50 Hz sinusoidal magnetic field on cell adhesion molecule expression in two human osteosarcoma cell lines (mg-63 and saos-2).Bioelectromagnetics,2003,24(5):327-338. |
| [3] | McLeod K J,Collazo L.Suppression of a differentiation response in MC-3T3-E1 osteoblast-like cells by sustained,low-level,30 Hz magnetic-field exposure.Radiation Research,2000,153(5):706-714. |
| [4] | Jansen J,van der Jagt O,Punt B,et al.Stimulation of osteogenic differentiation in human osteoprogenitor cells by pulsed electromagnetic fields:an in vitro study.BMC Musculoskeletal Disorders 2010,23(11):188-1-11. |
| [5] | Fini M,Cadossi R,Cane V,et al.The effect of pulsed electromagnetic fields on the osteointegration of hydroxyapatite implants in cancellous bone:a morphologic and microstructural in vivo study.J.Orthop.Res.,2002,20(4):756-763. |
| [6] | Zhang X Y,Xue Y,Zhang Y.Effects of 0.4 T rotating magnetic field exposure on density,strength,calcium and metabolism of rat thigh bones.Bioelectromagnetics,2006,27(1):1-9. |
| [7] | Chang K,Chang W H.Pulsed electromagnetic fields prevent osteoporosis in an ovariectomized female rat model:a prostaglandin E2-associated process.Bioelectromagnetics,2003,24(3):189-198. |
| [8] | Taylor K F,Inoue N,Rafiee B,et al.Effect of pulsed electromagnetic fields on maturation of regenerate bone in a rabbit limb lengthening model.J.Orthop.Res.,2006,24(1):2-10. |
| [9] | Wang L,Yang Z,Gao J,et al.A biocompatible method of decorporation:bisphosphonate-modified magnetite nanoparticles to remove uranyl ions from blood.J.Am.Chem.Soc.,2006,128(41):13358-13359. |
| [10] | Kim J,Lee J E,Lee J,et al.Magnetic fluorescent delivery vehicle using uniform mesoporous silica spheres embedded with monodisperse magnetic and semiconductor nanocrystals.J.Am.Chem.Soc.,2005,128(3):688-689. |
| [11] | Jun Y W,Huh Y M,Choi J S,et al.Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging.J.Am.Chem.Soc.,2005,127(16):5732-5733. |
| [12] | Wei Y,Zhang X H,Song Y,et al.Magnetic biodegradable Fe3O4/CS/PVA nanofibrous membranes for bone regeneration.Biomedical Materials,2011,6(5):055008. |
| [13] | Meng J,Zhang Y,Qi X,et al.Paramagnetic nanofibrous composite films enhance the osteogenic responses of pre-osteoblast cells.Nanoscale 2010,2(12):2565-2569. |
| [14] | Banobre-Lopez M,Pineiro-Redondo Y,De-Santis R,et al.Poly(caprolactone) based magnetic scaffolds for bone tissue engineering.J.Appl.Phys.,2011,109(7):07B313-1-3. |
| [15] | Bock N,Riminucci A,Dionigi C,et al.A novel route in bone tissue engineering:magnetic biomimetic scaffolds.Acta Biomaterialia,2010,6(3):786-796. |
| [16] | Wu Y,Jiang W,Wen X T,et al.A novel calcium phosphate ceramic-magnetic nanoparticle composite as a potential bone substitute.Biomedical Materials,2010,5(1):015001. |
| [17] | ]Morrison S Roy.赵壁英,刘英俊译.表面化学物理.北京:北京大学出版社,1984:238-242. |
| [18] | Sun S H,Zeng H.Size-controlled synthesis of magnetite nanoparticles.J.Am.Chem.Soc.,2002,124(28):8204-8205. |
| [19] | Kang Y S,Risbud S,Rabolt J F,et al.Synthesis and characterization of nanometer-size Fe3O4 and γ-Fe2O3 particles.Chemistry of Materials,1996,8(9):2209-2211. |
| [20] | Lan F,Liu K X,Jiang W,et al.Facile synthesis of monodisperse superparamagnetic Fe3O4/PMMA composite nanospheres with highmagnetization.Nanotechnology,2011,22(22):225604-1-7. |
| [21] | Lan F,Hu H,Jiang W,et al.Synthesis of superparamagnetic Fe3O4/PMMMa/SiO2 nanorattles with periodic mesoporous shell for lysozyme adsorption.Nanoscale,2012,4(7):2264-2267. |
| [22] | Jiang W,Wu Y,He B,et al.Effect of sodium oleate as a buffer on the synthesis of superparamagnetic magnetite colloids.J.Colloid Interface Sci.,2010,347(1):1-7. |
| [23] | Hing K A.Bioceramic bone graft substitutes:influence of porosity and chemistry.International Journal of Applied Ceramic Technology,2005,2(3):184-199. |
| [24] | 崔国文.缺陷、扩散与烧结.北京:清华大学出版社:1990:143-175. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%