采用"交替循环浸泡法(ALIM)"在TiO2纳米管管内填充类骨磷灰石,使磷灰石涂层由层状结构变为嵌入式结构,并考察填充量与TiO2纳米管结构间的关系,通过模拟体液浸泡实验评价其生物活性.结果表明,甘油体系(60V电压)中制备的纳米管填充效果最好;无定型的TiO2纳米管相比锐钛矿相的TiO2纳米管更能诱导类骨磷灰石的填充;采用ALIM于TiO2纳米管上填充类骨磷灰石可大大提高其生物活性.
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