生物制药研究中的多维色谱

色谱 , 2005, 23(1): 32-36. doi: 10.3321/j.issn:1000-8713.2005.01.007

生物制药研究中的多维色谱

田晶 ^1, , 路鑫 ^2, , 杨军 ^3, , 孔宏伟 ^4, , 王媛 ^5, , 赵欣捷 ^6, , 唐平 ^7, , 苑广志 ^8, , 许国旺 ^9,

1.中国科学院大连化学物理研究所,国家色谱研究分析中心,辽宁,大连,116011;大连轻工业学院分析中心,辽宁,大连,116001

2.中国科学院大连化学物理研究所,国家色谱研究分析中心,辽宁,大连,116011

3.中国科学院大连化学物理研究所,国家色谱研究分析中心,辽宁,大连,116011

4.中国科学院大连化学物理研究所,国家色谱研究分析中心,辽宁,大连,116011

5.中国科学院大连化学物理研究所,国家色谱研究分析中心,辽宁,大连,116011

6.中国科学院大连化学物理研究所,国家色谱研究分析中心,辽宁,大连,116011

7.中国科学院大连化学物理研究所,国家色谱研究分析中心,辽宁,大连,116011;吉林大学化学学院,吉林,长春,130021

8.中国科学院大连化学物理研究所,国家色谱研究分析中心,辽宁,大连,116011;大连轻工业学院分析中心,辽宁,大连,116001

9.中国科学院大连化学物理研究所,国家色谱研究分析中心,辽宁,大连,116011

基金项目: 国家高技术研究发展计划(863计划)(2003AA223061) 国家重点基础研究发展计划(973计划)(2003CB716003)

关键词：多维分离 , 色谱 , 联用技术 , 生物 , 制药 , 综述

Multidimensional Separations Used in Pharmaceutical and Biological Fields

对全二维气相色谱(GC×GC)、全二维液相色谱(HPLC×HPLC)、多维毛细管电泳等多维分离技术在生物制药研究中的应用进行了综述,其中对作者所在研究组在全二维气相色谱应用于中药及固相萃取-液相色谱联用分析系统等方面的工作做了重点介绍.由所综述的生物制药研究得出结论:多维分离方法以其高分辨、快速、自动化等特点已经在生物制药领域显示出它的巨大优势,并将发挥更大的作用.

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