采用有机泡沫浸渍工艺制备了高孔隙率的钙磷多孔陶瓷支架,将多孔陶瓷样品浸于明胶溶液中渗涂得到陶瓷/明胶复合支架;采用复合明胶涂层的方法对钙磷多孔陶瓷支架进行增强处理,在不破坏多孔支架孔隙特征的情况下,成功地在样品的孔壁上复合了明胶涂层.复合明胶涂层提高了样品的压缩强度和压缩模量,与未涂覆样品相比,涂敷样品受压时的应变特性发生了明显变化.尤其是渗涂5%明胶溶液的多孔样品,在保持高孔隙率(82.8%)的条件下其压缩强度和压缩模量分别由原来的1.04 MPa和0.105 GPa增加到5.17 MPa和0.325GPa.研究结果表明,孔壁上复合明胶涂层可以有效地增强多孔陶瓷支架.
参考文献
[1] | 左奕,李玉宝,张翔,等.纳米复合支架结构与生物学性能[J].复合材料学报,2005,22(6):32-36.Zuo Yi,Li Yubao,Zhang Xiang,et al.Structure and biologic properties of nano-composite scaffold[J].Acta Materiae Compositae Sinica,2004,22(6):32-36. |
[2] | Barralet J E,Grover L,Gaunt T,et al.Preparation of macroporous calcium phosphate cement tissue engineering scaffold[J].Biomaterials,2002,23(15):3063-3072. |
[3] | Almiralla A,Larrecqa G,Delgado J A.Fabrication of low temperature macroporous hydroxyapatite scaffolds by foaming and hydrolysis of an α-TCP paste[J].Biomaterials,2004,25(17):3671-3680. |
[4] | Hing K A,Best S M,Bonefield W.Characterization of porous hydroxyapatite[J].J Mater Sci Mater Med,1999,10(3):135-145. |
[5] | De Oliverira J F,De Aguiar P F,Rossi A M,et al.Effect of process parameters on the characteristics of porous calcium phosphate ceramics for bone tissue scaffolds[J].Int Soc Art Org,2003,27(3):406-411. |
[6] | Zhang Yu,Hockin H K X.Effects of synergistic reinforcement and absorbable fiber strength on hydroxyapatite bone cement[J].J Biomed Mater Res,2005,75A(4):832-840. |
[7] | 石宗利,王彦平,戴刚,等.CPP/PLLA软骨组织工程支架复合材料初步研究[J].复合材料学报,2002,19(6):97-100.Shi Zongli,Wang Yanping,Dai Gang,et al.CPP/PLLA composites of scaffolds for tissue engineering[J].Acta Materiae Compositae Sinica,2002,19(6):97-100. |
[8] | Ramay H R R,Zhang M.Biphasic calcium phosphate nanocomposite porous scaffolds for load bearing bone tissue engineering[J].Biomaterials,2004,25(21):5171-5180. |
[9] | Suyama S,Kameda T,Itoh Y.Effect of structure of interfacial coating layer on mechanical properties of continuous fiber reinforced reaction sintered silicon carbide matrix composite[J].Journal of Materials Science,2002,37(6):1101-1106. |
[10] | Miyazaki T,Ohtsuki C,Iwasaki H,et al.Organic modification of porous α-tricalcium phosphate to improve chemical durability[J].Materials Science Forum,2003,426(4):3201-3206. |
[11] | Miao X,Lim W K,Huang X,et al.Preparation and characterization of interpenetrating phased TCP/HA/PLGA composites[J].Materials Letters,2005,59(29/30):4000-4005. |
[12] | 董寅生,章庆国,刘斌,等.磷酸盐粘结羟基磷灰石多孔支架及其生物相容性的研究[J].生物医学工程杂志,2005,22(5):985-989.Dong Yinsheng,Zhang Qingguo,Liu Bin,et al.Study on hydroxyapatite porous scaffold bonded by phosphates and its biocompatibility[J].Journal of Biomedical Engineering,2005,22(5):985-989. |
[13] | 刘朝红,董寅生,刘斌,等.β-磷酸钙多孔生物陶瓷支架的制备及生物相容性[J].东南大学学报,2003,34(5):665-668.Liu Chaohong,Dong Yinshen,Liu Bin,et al.Preparation and biocompatibility of porous β-Ca3 (PO4) 2 scaffold[J].Journal of Southeast University,2003,34(5):665-668. |
[14] | Engin N Ozgür,Tas A Cüneyt.Manufacture of macroporous calcium hydroxyapatite bioceramics[J].Journal of the European Ceramic Society,1999,19(13/14):2569-2572. |
[15] | Wintermantel E,Mayer J,Blum J,et al.Tissue engineering scaffolds using superstructures[J].Biomaterials,1996,17(2):83-91. |
[16] | Ni Siyu,Chang Jiang,Chou Lee.A novel bioactive porous CaSiO3 scaffold for bone tissue engineering[J].J Biomed Mater Res,2006,76A(1):196-205. |
[17] | Fujishiro Y,Takahashi K,Sato T.Preparation and compressive strength of a-tricalcium phosphate/gelatin gel composite cement[J].J Biomed Mater Res,2001,54(4):525-530. |
[18] | 姚康德,伊玉姬.组织工程相关生物材料[M].北京:化学工业出版社,2003:49-83. |
[19] | 张玉军,张伟儒.结构陶瓷材料及其应用[M].北京:化学工业出版社,2005:76-109. |
[20] | Bigi A,Bracci B,Panzavolta S.Effect of added gelatin on the properties of calcium phosphate cement[J].Biomaterials,2004,25(14):2893-2899. |
[21] | 蒋挺大.胶原与胶原蛋白[M].北京:化学工业出版社,2006:28-30. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分:
-
10%
-
20%
-
30%
-
40%
-
50%