采用共沉淀方法制备了纳米羟基磷灰石/壳聚糖-硫酸软骨素复合材料,用XRD、SEM、EDS、TGA及万能材料实验机等对材料性能进行了分析表征,并观察了材料在模拟体液中培养后表面结构、形态以及体系pH值的变化.结果表明: 纳米羟基磷灰石/壳聚糖-硫酸软骨素复合材料具有良好的力学性能,对机体微环境影响微小、表面矿化效果好,有良好的生物活性和生物相容性.当羟基磷灰石含量为50%时,抗压强度为42.3 Mpa,该复合材料可满足骨组织修复与替代的要求,有望成为治疗骨缺损的承力替代物.
参考文献
| [1] | 杨兴生,孙静平.三七、菌灵芝、硫酸软骨素对家兔实验性动脉粥样斑块和血脂影响的初步报告[J].中华心血管病杂志,1973,1(4):6-11.Yang Xingsheng,Sun Jingping.The preliminary report of the effect of panax notoginseng,ganoderma lucidum,chondroitin sulfate on rabbit atherosclerotic speckle and serum lipids[J].Chinese Journal of Cardiology,1973,1(4):6-11. |
| [2] | 杨正菀,张尊仪,曾昭贤,等.国产硫酸软骨素A对心血管系统的药理作用及其毒性的初步研究药理学教研[J].中华医学杂志,1978,58(12):739-742.Yang Zhengwan,Zhang Zunyi,Zeng Zhaoxian,et al.Pharmacologic effect and toxicity of national product chondroitin sulfate A on cardiovascular system[J].National Medical Journal of China,1978,58(12):739-742. |
| [3] | 张天民,荣晓花,李小平.生化药物的研究与开发[J].中国生化药物杂志,1999,20(3):153-155.Zhang Tianmin,Rong Xiaohua,Li Xiaoping.Research and development of biochemical drugs[J].Chinese Journal of Biochemical Pharmaceutics,1999,20(3):153-155. |
| [4] | 曹鹏,刘万顺,韩宝芹,等.壳聚糖与硫酸软骨素共混膜的研究[J].中国生物医学工程学报,2005,24(1):43-49.Cao Peng,Liu Wanshun,Han Baoqin,et al.Studies on the properties of chitosan and chondroitin sulfate blend membrane[J].Chinese Journal of Biomedical Engineering,2005,24(1):43-49. |
| [5] | Li P,Ohtsuki C,Kokubo T,et al.Apatite formation induced by silica gel in a simulated body fluid[J].J Am Ceram Soc,1992,75:2094-2097. |
| [6] | Chen W,Qu S,Yang Z,et al.The histological observation of the early osteogenesis induced in porous calcium phosphate ceramics in muscular tissue of the dogs[J].Key Engineering Materials,1996,115:233-236. |
| [7] | Sailaja G S,Velayudhan S,Sunny M C,et al.Hydroxyapatite filled chitosan-polyacrylic acid polyelectrolyte complexes[J].Journal of Materials Science,2003,38:3653-3662. |
| [8] | Zhang Li,Li Yubao,Yang Aiping,et al.Preparation and in vitro investigation of chitosan/nano-hydroxyapatite composite used as bone substitute materials[J].Journal of Materials Science:Materials in Medicine,2005,16:213-219. |
| [9] | Atsushi Matsuda,Toshiyuki Ikoma,Hisatoshi Kobayashi,et al.Preparation and mechanical property of core-shell type chitosan/calcium phosphate composite fiber[J].Materials and Engineering,2004,24:723-728. |
| [10] | Yamaguchi I,Tokuchi K,Fukuzaki H,et al.Preparation and microstructure analysis of chitosan/hydroxyapatite nanocomposites[J].Journal of Biomedical Materials Research,2001,55(1):20-27. |
| [11] | Murugan R,Ramakrishna S.Bioreorbable composite bone paste using polysaccharide based nano hydroxyapatite[J].Biomaterials,2004,25:3829-3835. |
| [12] | 刘治.原位生长的纳米羟基磷灰石/壳聚糖基复合材料[D].四川:西南交通大学,2005.Liu Zhi.Preparation of nano-hydroxyapatite/chitosan composites via the in situ precipitation[D].Sichuan:Southwest Jiaotong University,2005. |
| [13] | 张福江,赵峰,尹玉姬,等.羟基磷灰石/壳聚糖-明胶网络复合材料在模拟体内环境中的特性及对兔桡骨缺损的修复[J].天津医药,2003,31(7):452-454.Zhang Fujiang,Zhao Feng,Yin Yuji,et al.Property of HA/CS-Gel composite in body micronenvironment and its influence on repairing radial defect of rabbits[J].Tianjin Med J,2003,31(7):452-454. |
| [14] | Zhang Y,Zhang M Q.Three-dimensional macroporous calcium phosphate bioceramics with nested chitosan sponges for load-bearing bone implants[J].J Biomed Mater Res,2002,61:1-8. |
| [15] | 马晓莉,姚子华,史大刚,等.多孔壳聚糖膜的制备及对水中游离氯的吸附性能[J].应用化学,2005,22(11):1214-1219.Ma Xiaoli,Yao Zihua,Shi Dagang,et al.Preparation of porous chitosan membranes and adsorption of free chloride in water by them[J].Chinese Journal of Applied Chemistry,2005,22(11):1214-1219. |
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