以磷灰石-硅灰石玻璃陶瓷(AW)粉和β-磷酸三钙(β-TCP)粉为原料.以硬脂酸为致孔剂.经模压成型、1170℃烧结制备磷灰石-硅灰石/β-磷酸三钙复合多孔支架材料(AW/β-TCP).采用X射线衍射(XRD)、扫描电镜(SEM)、能谱(EDS)、诱导耦合等离子体原子发射光谱(ICP-AES)等方法分析支架的晶相组成、显微结构、物理性能、生物活性和降解性.将大鼠骨髓间充质干细胞(rMSCs)与支架体外复合培养评价支架的生物相容性.结果表明:所制备的AW/β-TCP支架材料的抗压强度达14.3MPa.孔隙率达66.9%.孔径为100～700μm.具有良好的生物相容性、生物活性和降解性.可作为骨组织工程支架的候选材料.
参考文献
| [1] | De Aza P N,Gutian F,De Aza S.Biomaterials,1997,18 (19):1285-1291. |
| [2] | De Aza P N,Z.Lukinska B,Anseu M R,et al.Biomaterials,2000,21 (17):1735-1741. |
| [3] | Huang X,Jiang D L,Tan S H.Journal of Biomedical Materials Research,2004,69B (1):70-72. |
| [4] | 杨为中,周大利,尹光福,等(Yang W Z,et al).硅酸盐学报(Journal ofthe Chinese Ceramic Society),2004,32(2):171-176 |
| [5] | Ohtsuki C,Kokubo T,Yamamuro T.J Non Cryst Solids,1992,143:84-92. |
| [6] | Kim B S,Mooney D J.Trends Biotechnol,1998,16 (5):224-230. |
| [7] | 周大利,郑昌琼,尹光福,等(Zhou DL,et al).生物医学工程学杂志(Journal of Biomedical Engineering),1999,16(增刊):52-55. |
| [8] | Kokubo T.J Non Cryst Solids,1990,120 (1-2):138-151. |
| [9] | Han J,Chen R,Chen H Q,et al.J WCUMS,2001,32 (2):235. |
| [10] | Abiraman S,Varma H K,Kumari T V,et al.Bull.Mater.Sci.,2002,25 (5):419-429. |
| [11] | Matsuoka H,Akiyama H,Okada Y,et al.Journal of Biomedical Materials Research,1999,47 (2):176-188. |
| [12] | Hiroshi Fujita,Kazuhiro Ido,Yasutaka Matsuda,et al.Porous AW Glass Ceramic as a Femoral Intramedullary Plug.In:11th International Symposium on Ceramics in Medicine New York City,New York,USA,1998.645-648. |
| [13] | Teramoto H,Kawai A,Sugihara S,et al.Key Engineering Materials,2003,240-242:269-272. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%