研究氟化钕(NdF3)对大鼠肺、肝脏、肾脏和脾的毒性作用.将健康无特定病原体级雄性SD大鼠按体重随机分为70.0 mg/kg,210.0 mg/kg,280.0 mg/kg氟化钕染毒组和对照组.经气管注入法灌注染毒42天后,取出脏器,称重后计算脏器系数,并采用电感耦合等离子体质谱法测定NdF3水平.制作各脏器组织病理切片,光学显微镜下观察病理学改变.染毒组大鼠各脏器组织中氟化钕的含量均高于对照组(P＜0.01),且肝脏氟化钕含量高于肾和脑组织(P＜0.01).脏器病理切片结果显示各染毒组肺部均出现病理改变,且随染毒剂量增加肺病理改变趋于严重;中、高剂量组肝、肾、脾病理学均有改变.NdF3颗粒物可致染尘大鼠发生肺损伤,颗粒物可穿透肺泡进入体循环致大鼠肝脏、肾脏、脾脏损伤.
The chronic toxicity of rare earth neodymium fluoride (NdF3) to rats was studied in this paper.The specific pathogen free healthy male SD rats were randomly divided into four groups:control group,low dose group,middle dose group and high dose group.42 days after poisoned by intratracheal instillation,visceral organs of rats were removed and weighed.The organ coefficient was calculated.NdF3 content in organs of rats was dertermined by inductively coupled plasma mass spectrometry.Optical microcopy was used to observe the pathology of visceratissue section.Neodymium fluoride content in each organ in exposed rats was higher than the control group (P ＜ 0.01),and the liver neodymium fluoride content was higher than that in kidney and brain tissue (P ＜ 0.01).Organ pathological results show that lung pathological changes for all groups were obvious with the dose increasing,and the pathological changes in the lung tend to be serious;in the high dose group,liver,kidney and spleen pathology changed significantly.NdF3 dust particles can cause lung injury in rats,and the particles can also penetrate alveolar into the systemic circulation and lead to the liver,kidney and spleen injury in rats.
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