研究了芳香醛、乙酰乙酸乙酯和铵盐在水相中的催化Hantzsch反应,探讨了催化剂种类、反应底物比例、反应温度等因素对反应的影响.最终优化的最佳反应条件为:苯甲醛用量为5 mmol时,0.5 mmol DL-脯氨酸作催化剂,2.5 mmol碳酸铵为氨源,加入10 mL水,于70℃条件下反应5h,收率达90.1％.催化剂可循环利用,芳香醛底物具有广泛的适用性,产物结构经红外、核磁等技术手段确定.反应具有环境友好、条件温和、操作简便、产率较高等优点.结果表明,该水相催化Hantzsch反应具有广泛的适用性.
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