为了研究生物修饰对材料表面抗菌性能的影响,利用多巴胺及三种生物多肽修饰304不锈钢的表面,利用傅里叶变换红外光谱仪(FTIR)和接触角测量仪研究修饰后的材料表面性质,选用金黄色葡萄球菌(S.aureus)作为试验菌株研究样本表面抗菌性能,并通过超景深三维显微系统初步研究了样本表面形貌对抗菌性能的影响.结果表明,多巴胺和生物肽修饰后,样本表面的湿润性发生了改变,且都具有抗菌效果,1号多肽抗菌效果最好,多巴胺修饰样本的抗菌效果最差;不同颗粒度砂纸、不同抛磨压力处理的样本表面会影响材料表面性能,600号砂纸抛光的样本经生物修饰后抗菌效果优于2 000号砂纸抛光的样本,这个结论同样适用于开放环境中.
In order to study the effect of biological modification on the antibacterial properties,the surface of 304 stainless steel was modified with dopamine and three kinds of biological peptides.The surface properties of the modified materials were studied by Fourier transform infrared spectroscopy (FTIR) and contact angle measuring instrument.S.aureus was used as the experimental strain to study the antimicrobial properties of the samples,and the effects of sample morphology on the antibacterial properties were also studied by super depth 3D microscope.The results show that the wettability of samples treated by dopamine and peptides are changed,and all of them reveal antibacterial effect,polypeptide 1 has the best antibacterial effect,while the samples treated by dopamine show the worst antibacterial properties.Antibacterial properties of the material are related with polishing pressure and particle size sandpaper.Samples polished by 600# sandpaper show better antibacterial properties than those polished by 2000# sandpaper after biological modification.The obove conclusion is also applicable to open environment.
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