以胶原、聚乙烯醇为原料,首先研究了两者不同配比共混液的流变性能,结果表明胶原-聚乙烯醇共混液的黏度随剪切速率增大而减小、随温度升高而降低;采用幂律方程拟合胶原-聚乙烯醇共混液流动曲线并计算了非牛顿指数,温度升高,非牛顿指数增大,向1靠近,牛顿特性突出.再以胶原与聚乙烯醇固含量配比(质量比)1∶1、1∶2、2∶1的共混液进行静电纺丝,实验结果显示胶原和聚乙烯醇配比为1∶1的纤维直径分布最宽,1∶2和2∶1的纤维直径分布较窄,均可明显看到胶原纤维与聚乙烯醇纤维纵横交错形成更稳固的纤维网结构,最终得到的胶原-聚乙烯醇静电纺的最佳配比为固含量2∶1.聚乙烯醇与胶原共混后静电纺丝制备的微纳纤维膜可充分发挥两者的优点,有望在今后用于血管支架、创伤敷料、止血纤维等方面.
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