纳米CeO2由于自身的结构特点,Ce4和Ce3+在纳米粒子上共存,遇到氧化剂ROS,Ce3+被氧化成Ce4+,因此它是一种还原剂.当周围环境改变时,它又有再生能力,从Ce4+再生为Ce3+,这也是CeO2的本质(有氧空穴)所决定的.这个性质使纳米CeO2在生物医药上有很多应用,可以模拟SOD,CAT催化活性清除超氧阴离子自由基、过氧化氢分子、羟基自由基等对人体有害的ROS.有重点地例举了纳米CeO2在癌症放疗中作为辅助剂的应用,对神经细胞的保护,防止过早蜕化,特别是对视网膜的保护.简述了纳米CeO2的制备进展,更有效的和更长效的纳米CeO2的研制进展.
参考文献
| [1] | Buonocore G;Perrone S;Tataranno ML.Oxygen toxicity: chemistry and biology of reactive oxygen species.[J].Seminars in fetal & neonatal medicine,20104(4):186-190. |
| [2] | A. Bobba;G. Amadoro;D. Valenti;V. Corsetti;R. Lassandro;A. Atlante.Mitochondrial respiratory chain Complexes I and IV are impaired by beta-amyloid via direct interaction and through Complex I-dependent ROS production, respectively[J].Mitochondrion,20134(4):298-311. |
| [3] | 郭金玲;李常燕;胡长峰;沈岳年.活性氧和纳米氧化铈的结构特征及其应用前景[J].化学通报（印刷版）,2014(2):146-149. |
| [4] | 崔剑;李兆陇;洪啸吟.自由基生物抗氧化与疾病[J].清华大学学报（自然科学版）,2000(6):9-12. |
| [5] | 戴甲培;石悦.活性氧双向生物学效应和机制[J].中南民族大学学报：自然科学版,2012(3):43-51. |
| [6] | Tarnuzzer RW;Colon J;Patil S;Seal S.Vacancy engineered ceria nanostructures for protection from radiation-induced cellular damage[J].Nano letters,200512(12):2573-2577. |
| [7] | Heckert EG;Karakoti AS;Seal S;Self WT.The role of cerium redox state in the SOD mimetic activity of nanoceria.[J].Biomaterials,200818(18):2705-2709. |
| [8] | Ying Xue;Qingfen Luan;Dan Yang.Direct Evidence for Hydroxyl Radical Scavenging Activity of Cerium Oxide Nanoparticles[J].The journal of physical chemistry, C. Nanomaterials and interfaces,201111(11):4433-4438. |
| [9] | Schubert D;Dargusch R;Raitano J;Chan SW.Cerium and yttrium oxide nanoparticles are neuroprotective[J].Biochemical and Biophysical Research Communications,20061(1):86-91. |
| [10] | Das M;Patil S;Bhargava N;Kang JF;Riedel LM;Seal S;Hickman JJ.Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons[J].Biomaterials,200710(10):1918-1925. |
| [11] | Kong L;Cai X;Zhou X;Wong LL;Karakoti AS;Seal S;McGinnis JF.Nanoceria extend photoreceptor cell lifespan in tubby mice by modulation of apoptosis/survival signaling pathways.[J].Neurobiology of disease,20113(3):514-523. |
| [12] | Cai,X.;Sezate,S.A.;Seal,S.;McGinnis,J.F..Sustained protection against photoreceptor degeneration in tubby mice by intravitreal injection of nanoceria[J].Biomaterials,201234(34):8771-8781. |
| [13] | Francesca Pagliari;Corrado Mandoli;Giancarlo Forte;Eugenio Magnani;Stefania Pagliari;Giorgia Nardone;Silvia Licoccia;Marilena Minieri;Paolo Di Nardo;Enrico Traversa.Cerium Oxide Nanoparticles Protect Cardiac Progenitor Cells from Oxidative Stress[J].ACS nano,20125(5):3767-3775. |
| [14] | Nagy, K;Dekany, I.Preparation of nanosize cerium oxide particles in W/O microemulsions[J].Colloids and Surfaces, A. Physicochemical and Engineering Aspects,20091/3(1/3):31-40. |
| [15] | Soumitra Kar;Chetak Patel;Swadeshmukul Santra.Direct Room Temperature Synthesis of Valence State Engineered Ultra-Small Ceria Nanoparticles: Investigation on the Role of Ethylenediamine as a Capping Agent[J].The journal of physical chemistry, C. Nanomaterials and interfaces,200912(12):4862-4867. |
| [16] | Liu, X.;Wei, W.;Yuan, Q.;Zhang, X.;Li, N.;Du, Y.;Ma, G.;Yan, C.;Ma, D..Apoferritin-CeO _2 nano-truffle that has excellent artificial redox enzyme activity[J].Chemical communications,201226(26):3155-3157. |
| [17] | 吕广明;王艳杰;刘瑞;孙聆东;黄云辉;严纯华.纳米氧化铈的抗氧化生物应用[J].中国科学（化学）,2013(10):1309-1321. |
| [18] | Weaver, Jessica D.;Stabler, Cherie L..Antioxidant cerium oxide nanoparticle hydrogels for cellular encapsulation[J].Acta biomaterialia,2015:136-144. |
| [19] | Wang Yuejuan;Ma Jingmeng;Luo Mengfei.Preparation of High-Surface Area Nano-CeO2 by Template-Assisted Precipitation Method[J].Journal of Rare Earths,20071(1):58-62. |
| [20] | 徐灿;曲晓刚.稀土二氧化铈在生物领域的最新研究进展[J].中国科学（化学）,2014(4):506-520. |
| [21] | Asati, A.;Santra, S.;Kaittanis, C.;Perez, J.M..Surface-charge-dependent cell localization and cytotoxicity of cerium oxide nanoparticles[J].ACS nano,20109(9):5321-5331. |
| [22] | Gruber, Jan;Fong, Sheng;Chen, Ce-Belle;Yoong, Sialee;Pastorin, Giorgia;Schaffer, Sebastian;Cheah, Irwin;Halliwell, Barry.Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing[J].Biotechnology Advances: An International Review Journal,20135(5):563-592. |
| [23] | Ibanez, Irene L.;Notcovich, Cintia;Catalano, Paolo N.;Bellino, Martin G.;Duran, Hebe.The redox-active nanomaterial toolbox for cancer therapy[J].Cancer letters,20151(1):9-19. |
| [24] | Emadi A;Gore SD.Arsenic trioxide - An old drug rediscovered.[J].Blood reviews,20104/5(4/5):191-199. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%