A carbon paste electrode (CPE) modified with ferrocene carboxylic acid (FcCA) and TiO2 nanoparticles was constructed by incorporating TiO2 nanoparticles and ferrocene carboxylic acid into the carbon paste matrix.The electrochemical behavior of captopril (CAP) at the surface of the modified electrode was investigated using electroanalytical methods.The modified electrode showed excellent electrocatalytic activity for the oxidation of CAP in aqueous solutions at physiological pH values.Cyclic voltammetric curves showed that the oxidation of CAP at the surface of the modified electrode reduced its overpotential by more than 290 mV.The modified electrode was used for detecting captopril using cyclic voltammetry and square wave voltammetry techniques.A calibration curve in the range of 0.03 to 2400μmol/L was obtained that had a detection limit of 0.0096 μmol/L (3σ) under the optimized conditions.The modified electrode was successfully used for the determination of captopril in pharmaceutical and biological samples.
参考文献
| [1] | Cushman D W;Cheung H S;Sabo E F;Ondetti M A .[J].Biochemistry,1978,16:5484. |
| [2] | Klein J;Colin P;Scherer E;Levy M Koren G .[J].Therapeutic Drug Monitoring,1990,12:105. |
| [3] | Duchin K L;McKinstry D N;Cohen A L;Migdalof B H .[J].Clinical Pharmacokinetics,1988,14:241. |
| [4] | Boyer J;Liu R H .[J].Nutrition,2004,3:1. |
| [5] | Demirkol O;Ercal N .Biologically Important Thiols in Various Vegetables and Fruits.[J].Journal of Agricultural and Food Chemistry,2004(26):8151-8154. |
| [6] | Arakawa M;Ushimaru N;Osada N;Oda T;Ishige K;Ito Y .N-acetylcysteine selectively protects cerebellar granule cells from 4-hydroxynonenal-induced cell death.[J].Neuroscience Research: The Official Journal of the Japan Neuroscience Society,2006(3):255-263. |
| [7] | Fang Y Z;Yang S;Wu G .[J].Nutrition,2002,18:872. |
| [8] | Zhang XR.;Vanderweken G.;Calokerinos AC.;Nakashima K.;Baeyens WRG. .CHEMILUMINESCENCE DETERMINATION OF CAPTOPRIL BASED ON A RHODAMINE B SENSITIZED CERIUM(IV) METHOD[J].Analytica chimica acta,1995(1):121-125. |
| [9] | Xinrong Z;Baeyens W R G;Van der Weken G;Calokerinos A C Nakashima K .[J].Journal of Pharmaceutical and Biomedical Analysis,1995,13:425. |
| [10] | Sastry CSP;Srinivas KR;Prasad KMMK .SPECTROPHOTOMETRIC DETERMINATION OF BIO-ACTIVE COMPOUNDS IN COMMERCIAL SAMPLES WITH NITROUS ACID AND CRESYL FAST VIOLET ACETATE[J].Analytical Letters,1996(8):1329-1349. |
| [11] | Askal H F .[J].TALANTA,1991,38:1155. |
| [12] | El-ashry S M;Ibrahim F A .[J].Analytical Letters,1992,25:1657. |
| [13] | Panderi I;Parissi-poulou M .[J].International Journal of Pharmaceutics,1992,86:99. |
| [14] | Emara K M;Mohamed A M I;Askal H F;Darwish I A .[J].Analytical Letters,1993,26:2385. |
| [15] | Sastry C S P;Rao S G;Naidu P Y;Srinivas K R .[J].Analytical Letters,1998,31:263. |
| [16] | Squella J A;Lemus I;Borges Y;Nevgara-Vergara I J .[J].Bol Soc Chilena Quim,1992,37:259. |
| [17] | de Oliveira I R W Z;Vieira I C .[J].Enzyme and Microbial Technology,2006,38:449. |
| [18] | de Oliveira I R W Z;Femandes S C;Vieira I C .[J].Journal of Pharmaceutical and Biomedical Analysis,2007,40:661. |
| [19] | de Oliveira I R W Z;Os'orio R E-H M B;Neves A;Vieira I C .[J].Sensors and Actuators B: Chemical,2007,122:89. |
| [20] | Stefan R I;van Staden J F;Aboul-Enein H Y .[J].TALANTA,2000,51:969. |
| [21] | Wakabayashi H;Yamato S;Nakajima M;Shimada K .[J].Journal of Pharmaceutical and Biomedical Analysis,1994,12:1147. |
| [22] | Siangproh W.;Ngamukot P.;Chailapakul O. .Electrochemical determination of captopril at boron-doped diamond thin film electrode applied to a flow injection system[J].Sensors and Actuators, B. Chemical,2003(1/3):60-66. |
| [23] | Ghicov A;Macak JM;Tsuchiya H;Kunze J;Haeublein V;Frey L;Schmuki P .Ion implantation and annealing for an efficient N-doping of TiO2 nanotubes[J].Nano letters,2006(5):1080-1082. |
| [24] | Wang L;Bai JY;Huang PF;Wang HJ;Zhang LY;Zhao YQ .Self-assembly of gold nanoparticles for the voltammetric sensing of epinephrine[J].Electrochemistry communications,2006(6):1035-1040. |
| [25] | Navio JA.;Pradera MA.;Morales E.;Gomez-Ariza JL.;Cerrillos C. .Photoassisted degradation (in the UV) of phenyltin(IV) chlorides in the presence of titanium dioxide[J].Langmuir: The ACS Journal of Surfaces and Colloids,1998(2):388-395. |
| [26] | Ranjit K T;Willner I .[J].Journal of Physical Chemistry B,1998,102:9397. |
| [27] | Chang C P;Chen J N;Lu M C;Yang H Y .[J].Chemosphere,2005,58:1071. |
| [28] | Kim S B;Hong S C .[J].Applied Catalysis B:Environmental,2002,35:305. |
| [29] | O'Regan B;Gratzel M .[J].Nature,1991,353:737. |
| [30] | Macak JM;Barczuk PJ;Tsuchiya H;Nowakowska MZ;Ghicov A;Chojak M;Bauer S;Virtanen S;Kulesza PJ;Schmuki P .Self-organized nanotubular TiO2 matrix as support for dispersed Pt/Ru nanoparticles: Enhancement of the electrocatalytic oxidation of methanol[J].Electrochemistry communications,2005(12):1417-1422. |
| [31] | Raoof, JB;Ojani, R;Baghayeri, M .Simultaneous electrochemical determination of glutathione and tryptophan on a nano-TiO2/ferrocene carboxylic acid modified carbon paste electrode[J].Sensors and Actuators, B. Chemical,2009(1):261-269. |
| [32] | Bard A J;Faulkner L R.Electrochemical Methods,Fundamentals and Applications[M].New York:wiley,2001 |
| [33] | Dong S J;Che LG;Xie Y W.Chemical Modified Electrode[M].北京:科学出版社,2003 |
| [34] | Raoof JB;Ojani R;Chekin F .Electrochemical analysis of D-penicillamine using a carbon paste electrode modified with ferrocene carboxylic acid[J].Electroanalysis,2007(18):1883-1889. |
| [35] | Raoof J B;Ojani R;Kolbadinezhad M .[J].Journal of Solid State Electrochemistry,2009,13:1411. |
| [36] | Raoof J B;Ojani R;Chekin F .[J].Journal of Chemical Sciences,2009,121:1083. |
| [37] | Raoof J B;Ojani R;Kiani A .[J].Journal of Electroanalytical Chemistry,2001,515:45. |
| [38] | Zhou M;Ding J;Guo L;Shang Q .[J].Analytical Chemistry,2007,79:5328. |
| [39] | Beitollahi, H.;Raoof, J.-B.;Hosseinzadeh, R. .Application of a Carbon-Paste Electrode Modified with 2,7-Bis(ferrocenyl ethyl)fluoren-9-one and Carbon Nanotubes for Voltammetric Determination of Levodopa in the Presence of Uric Acid and Folic Acid[J].Electroanalysis,2011(8):1934-1940. |
| [40] | Pournaghi-Azar M H;Razmi-Nerbin H .[J].Journal of Electroanalytical Chemistry,2000,488:17. |
| [41] | Kuo K N;Murray R W .[J].Journal of Electroanalytical Chemistry,1982,131:37. |
| [42] | Galus Z.Fundamentals of Electrochemical Analysis[M].New York:Ellis Horwood,1976 |
| [43] | Wang J.Analytical Electrochemistry[M].New York:wiley,2000 |
| [44] | Vaughan N P;Milligan B D;Ogden T L .[J].Analyst,1987,112:199. |
| [45] | Shahrokhian S;Karimi M;Khajehsharifi H .[J].Sensors and Actuators B: Chemical,2005,109:278. |
| [46] | Rezaei B;Damiri S .Voltammetric behavior of multi-walled carbon nanotubes modified electrode-hexacyanoferrate(II) electrocatalyst system as a sensor for determination of captopril[J].Sensors and Actuators, B. Chemical,2008(1):324-331. |
| [47] | Karimi-Maleh H;Ensafi A A;Allafchian A R .[J].Journal of Solid State Chemistry,2010,14:9. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%