一锅法绿色合成烯酰胺和1,3-二炔

催化学报 , 2015, (1): 113-118. doi: 10.1016/S1872-2067(14)60220-5

一锅法绿色合成烯酰胺和1,3-二炔

1.西北大学化学与材料科学学院，合成与天然功能分子化学教育部重点实验室，陕西西安710127

2.西北大学化学与材料科学学院，合成与天然功能分子化学教育部重点实验室，陕西西安710127

3.西北大学化学与材料科学学院，合成与天然功能分子化学教育部重点实验室，陕西西安710127

4.西北大学化学与材料科学学院，合成与天然功能分子化学教育部重点实验室，陕西西安710127

基金项目: 陕西省科技厅“陕西省青年科技新星”基金(2012KJXX-26) the Fund of the Rising Stars of Shaanxi Province (2012KJXX-26).基金来源:国家自然科学基金(21272183) the National Natural Science Foundation of China(21272183)

关键词：绿色合成 , 酮肟 , 末端炔 , 烯酰胺 , 1,3-二炔

One-pot green synthesis of enamides and 1,3-diynes

Keywords： Green synthesis , Ketoxime , Terminal alkyne , Enamide , 1,3-Diyne

结合绿色化学概念,将酮肟还原酰化和末端炔氧化偶联在一锅进行反应,发展了一种Pd/Cu协同催化一锅绿色合成烯酰胺和1,3-二炔的新方法。该方法无需外加任何氧化剂和还原剂,可同时得到烯酰胺和1,3-二炔,产率高,反应条件温和。

A green organic synthetic method combining reductive acylation of ketoximes and oxidative cou‐pling of terminal alkynes was developed. This novel process enables enamides and 1,3‐diynes to be synthesized simultaneously in high yields and under mild conditions without the use of terminal reductants/oxidants.

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