Preparation of Lung Targeting Microspheres of Gelatin Ceftiofur Alkali

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1.Laboratory of Chemical and Biological College of Chemistry and Pharmacy, Qingdao Agricultural University, Qingdao 266109, China

2.Qingdao Continent Pharmaceutical Co.Ltd., Qingdao 266061, China

3.Laboratory of Chemical and Biological College of Chemistry and Pharmacy, Qingdao Agricultural University, Qingdao 266109, China

4.China Institute of Veterinary Drug Control, Beijing 100081, China

5.China Institute of Veterinary Drug Control, Beijing 100081, China

6.Laboratory of Chemical and Biological College of Chemistry and Pharmacy, Qingdao Agricultural University, Qingdao 266109, China

7.Laboratory of Chemical and Biological College of Chemistry and Pharmacy, Qingdao Agricultural University, Qingdao 266109, China

1.Laboratory of Chemical and Biological College of Chemistry and Pharmacy, Qingdao Agricultural University, Qingdao 266109, China

2.Qingdao Continent Pharmaceutical Co.Ltd., Qingdao 266061, China

3.Laboratory of Chemical and Biological College of Chemistry and Pharmacy, Qingdao Agricultural University, Qingdao 266109, China

4.China Institute of Veterinary Drug Control, Beijing 100081, China

5.China Institute of Veterinary Drug Control, Beijing 100081, China

6.Laboratory of Chemical and Biological College of Chemistry and Pharmacy, Qingdao Agricultural University, Qingdao 266109, China

7.Laboratory of Chemical and Biological College of Chemistry and Pharmacy, Qingdao Agricultural University, Qingdao 266109, China

[1]	Rojas J;Pinto Alphandary-H;Leo E;Pecquet S;Couvreur P;Fattal E .Optimization of the encapsulation and release of beta-lactoglobulin entrapped poly(DL-lactide-co-glycolide) microspheres.[J].International Journal of Pharmaceutics,1999(1):67-71.
[2]	Zolnik BS;Leary PE;Burgess DJ .Elevated temperature accelerated release testing of PLGA microspheres[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2006(3):293-300.
[3]	Wagner RD;Johnson SJ;Cerniglia CE;Erickson BD .Bovine intestinal bacteria inactivate and degrade ceftiofur and ceftriaxone with multiple beta-lactamases.[J].Antimicrobial Agents and Chemotherapy,2011(11):4990-4998.
[4]	Berendsen, B. J. A;Stolker, L. A. A. M;Nielen, M. W. F. .Assessment of liquid chromatography-tandem mass spectrometry approaches for the analysis of ceftiofur metabolites in poultry muscle.[J].Food Additives & Contaminants, Part A. Chemistry, Analysis, Control, Exposure & Risk Assessment,2012(2):197-207.

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