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材料科学技术（英文）, 2016, 32(9): 845-857.
10.1016/j.jmst.2016.06.021
Enhanced Anti-corrosion Ability and Biocompatibility of PLGA Coatings on MgZnYNd Alloy by BTSE-APTES Pre-treatment for Cardiovascular Stent

Liu Jing 1, , Xi Tingfei 1,2,*,,

1. Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China;
2. Shenzhen Institute, Peking University, Shenzhen 518055, China

Bioabsorbable magnesium alloys are widely studied for various implant applications, as they reduce the risks such as severe inflammatory response existing in permanent metallic implants. However, the over-fast corrosion rate of magnesium alloy is usually an obstacle in biomedical applications. Here we report a simple two-step reaction to introduce anticorrosive silane pre-treatment on MgZnYNd alloys before coating with poly (glycolide-co-lactide) (PLGA). The first step is to immerse the NaOH-activated MgZnYNd with bistriethoxysilylethane (BTSE) to form a cross-linked silane coating layer with enhanced corrosion resistance; the second step involves immobilizing amine functional groups for forming hydrogen bond with outer PLGA coating by treating the BTSE-modified MgZnYNd with 3-amino-propyltrimethoxysilane (APTES). We characterized the BTSE-APTES pre-treated PLGA coating on MgZnYNd by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), static contact angle and Acid Orange 7 measurement. Nano-scratch test was to verify that the scratch resistance of the PLGA coating with BTSE-APTES pre-treatment was superior to direct PLGA coating. Standard electrochemical measurements along with the long-term immersion results indicated that the BTSE-APTES pre-treatment rendered better in vitro degradation behavior. Cell adhesion and cell viability tests with both vascular smooth muscle cells (VSMC) and human umbilical vein endothelial cells (EA. hy926) demonstrated that BTSE-APTES pre-treated MgZnYNd substrate had significantly more beneficial effects. The favorable anti-corrosion behavior and biocompatibility of BTSE-APTES pre-treated PLGA coatings on MgZnYNd alloy suggest that the novel two-step silanization procedure may have the great potential to enhance the performance of the magnesium-based biomaterials and provide a valid solution for the conversion modification of cardiovascular implants, taking the magnesium-based bioabsorbable materials closer to clinical application.

引用： Liu Jing, Xi Tingfei Enhanced Anti-corrosion Ability and Biocompatibility of PLGA Coatings on MgZnYNd Alloy by BTSE-APTES Pre-treatment for Cardiovascular Stent. 材料科学技术（英文）, 2016, 32(9): 845-857. doi: 10.1016/j.jmst.2016.06.021
参考文献：
[1] B. Heublein, R. Rohde, V. Kaese, M. Niemeyer, W. Hartung, A. Haverich.Heart, 89(2003), pp. 651-656
[2] R. Erbel, C. Di Mario, J. Bartunek, J. Bonnier, B. de Bruyne, F.R. Eberli, P. Erne, M. Haude, B. Heublein, M. Horrigan, C. Ilsley, D. B?se, J. Koolen, T.F. Lüscher, N. Weissman, R. Waksman. Lancet, 369(2007), pp. 1869-1875
[3] F. Wittea, J. Fischera, J. Nellesenb, H.A. Crostackb, V. Kaesec, A. Pischd, F. Beckmanne, H. Windhagena.Biomaterials, 27(2006), pp. 1013-1018
[4] M.P. Staiger, A.M. Pietak, J. Huadmai, G. Dias.Biomaterials, 27(2006), pp. 1728-1734
[5] M.B. Kannan, R.K. Raman.Biomaterials, 29(2008), pp. 2306-2314
[6] L. Choudhary, R.K. Raman.Acta Biomater, 8(2012), pp. 916-923
[7] F. Witte.Acta Biomater, 6(2010), pp. 1680-1692
[8] B. Wang, S. Guan, J. Wang, L. Wang, S. Zhu. Mater.Sci. Eng. B, 176(2011), pp. 1673-1678
[9] L. Mao, G. Yuan, S. Wang, J. Niu, G. Wu, W. Ding. Mater.Lett, 88(2012), pp. 1-4
[10] G. Jin, H. Qin, H. Cao, S. Qian, Y. Zhao, X. Peng, X. Zhang, X. Liu, P.K. Chu.Biomaterials, 35(2014), pp. 7699-7713
[11] C. Blawert, W. Dietzel, E. Ghali, G. Song. Adv.Eng. Mater, 8(2006), pp. 511-533
[12] M. Abulsain, A. Berkani, F.A. Bonilla, Y. Liu, M.A. Arenas, P. Skeldon, G.E. Thompson, P. Bailey, T.C.Q.Noakes, K. Shimizu, H. Habazaki. Electrochim. Acta, 49(2004), pp. 899-904
[13] Y. Chen, G. Wan, J. Wang, S. Zhao, Y. Zhao, N. Huang. Corros.Sci, 75(2013), pp. 280-286
[14] M.D. Pereda, C. Alonso, L. Burgos-Asperilla, J.A. del Valle, O.A. Ruano, P. Perez, M.A. Fernandez Lorenzo de Mele. Acta Biomater, 6(2010), pp. 1772-1782
[15] X.L. Wang, N. Haraikawa, S. Suda. J.Alloy. Compd, 231(1995), pp. 397-402
[16] T. Yan, L. Tan, D. Xiong, X. Liu, B. Zhang, K. Yang. Mater.Sci. Eng. C, 30(2010), pp. 740-748
[17] M.S. Killian, V. Wagener, P. Schmuki, S. Virtanen.Langmuir, 26(2010), pp. 12044-12048
[18] X. Liu, Z. Yue, T. Romeo, J. Weber, T. Scheuermann, S. Moulton, G. Wallace.Acta Biomater, 9(2013), pp. 8671-8677
[19] R. Pinto, M.J. Carmezim, M.G.S.Ferreira, M.F. Montemor. Prog. Org. Coat, 69(2010), pp. 143-149
[20] F. Zucchi, V. Grassi, A. Frignani, C. Monticelli, G. Trabanelli. Surf.Coat. Tech, 200(2006), pp. 4136-4143
[21] F. Zucchi, A. Frignani, V. Grassi, A. Balbo, G. Trabanelli. Mater.Chem. Phys, 110(2008), pp. 263-268
[22] E.P. Plueddemann, Berlin, 1991.
[23] W.J. van Ooij, D.Q. Zhu, G. Prasad, S. Jayaseelan, Y. Fu, N. Teredesai. Surf. Eng, 16(2000), pp. 386-396
[24] C.R. Jenney, K.M.DeFife, E. Colton, J.M. Anderson. In: Proceedings of 24th Annual Meeting of the Society for Biomaterials, San Diego, CA, (1998)
[25] M. Pagliaro. Silica-based materials for advanced chemical applications, CNR, Instituto per lo Studiodei Materiali Nanostrutturati and Institute for Scientific Methodology, Palermo, Italy, (2009)
[26] C. Kirchner, T. Liedl, S. Kudera, T. Pellegrino, A.M. Javier, H.E. Gaub, S. Stolzle, N. Fertig, W.J. Parak.Nano Lett, 5(2004), pp. 331-338
[27] R. Müller, J. Abke, E. Schnell, F. Macionczyk, U. Gbureck, R. Mehrl, Z. Ruszczak, R. Kujat, C. Englert, M. Nerlich, P. Angele.Biomaterials, 26(2005), pp. 6962-6972
[28] D. Zhu, W.J. van Ooij. Corros. Sci, 45(2003), pp. 2177-2197
[29] J. Song, W.J. van Ooij. J. Adhes. Sci. Technol, 17(2003), pp. 2191-2221
[30] L. Xu, A. Yamamoto.Colloids Surf B Biointerfaces, 93(2012), pp. 67-74
[31] A. Mandelli, M. Bestetti, A. Da Forno, N. Lecis, S.P. Trasatti, M. Trueba. Surf.Coat. Technol, 205(2011), pp. 4459-4465
[32] J.N. Li, P. Cao, X.N. Zhang, S.X. Zhang, Y.H. He. J. Mater.Sci, 45(2010), pp. 6038-6045
[33] X.N. Gu, N. Li, W.R. Zhou, Y.F. Zheng, X. Zhao, Q.Z. Cai, L. Ruan.Acta Biomater, 7(2011), pp. 1880-1889
[34] A. Abdal-hay, M. Dewidar, J.K. Lim. Appl. Surf. Sci, 261(2012), pp. 536-546
[35] B.S. Kopf, A. Schipanski, M. Rottmar, S. Berner, K. Maniura-Weber.Acta Biomater, 19(2015), pp. 180-190
[36] Q.H. Zhou, J. Xie, M. Bao, H.H. Yuan, Z.Y. Ye, X.X. Lou, Y.Z. Zhang. J. Mater. Chem.B, 3(2015), pp. 4439-4450
[37] D. Susac, X. Sun, K.A.R.Mitchell. Appl. Surf. Sci, 207(2003), pp. 40-50
[38] J. Liu, X.L. Liu, T.F. Xi, C.C. Chu. J. Mater. Chem.B, 3(2015), pp. 878-893
[39] D. Zhu, W.J. van Ooij. Prog. Org. Coat, 49(2004), pp. 42-53
[40] G. Li, P. Yang, Y. Liao, N. Huang.Biomacromolecules, 12(2011), pp. 1155-1168
[41] C.Y. Wu. University of Science and Technology Beijing. Ph.D. thesis (2011) in Chinese
[42] M.F. Montemor, M.G.S.Ferreira. Prog. Org. Coat, 60(2007), pp. 228-237
[43] X. Lu, Y. Zuo, X. Zhao, Y. Tang. Corros.Sci, 60(2012), pp. 165-172
[44] W. Tang, X. Weng, L. Deng, K. Xu, J. Lu. Surf.Coat. Technol, 201(2007), pp. 5664-5666
[45] D. Song, X. Jing, J. Wang, P. Yang, Y. Wang, M. Zhang. J.Alloy. Compd, 510(2012), pp. 66-70
[46] R. Arrabal, E. Matykina, F. Viejo, P. Skeldon, G.E. Thompson.Corros. Sci, 50(2008), pp. 1744-1752
[47] H. Ardelean, I. Frateur, P. Marcus. Corros.Sci, 50(2008), pp. 1907-1918
[48] C.N. Cao.Principles of Electrochemistry of Corrosion. (3rd ed.)Chemical Industry Press, Beijing, China(2008), p. 139
[49] G. Baril, N. Pebere. Corros.Sci, 43(2001), pp. 471-484
[50] X.L. Liu, Z. Zhen, J. Liu, T.F. Xi, Y.D. Zheng, S.K. Guan, Y.F. Zheng, Y. Cheng. J.Mater. Sci. Technol, 31(2015), pp. 733-743
[51] T.F. da Conceicao, N. Scharnagl, C. Blawert, W. Dietzel, K.U. Kainer. Thin Solid Films, 518(2010), pp. 5209-5218
[52] E.M. Sherif, A.A. Almajid.Int. J. Electrochem. Sci, 6(2011), pp. 2131-2148
[53] Y. Cheng, T. Qin, H. Wang, Z. Zhang. Trans.Nonferrous Met. Soc. China, 19(2009), pp. 517-524
[54] X. Lin, X. Yang, L. Tan, M. Li, X. Wang, Y. Zhang, K. Yang, Z. Hu, J. Qiu. Appl.Surf. Sci, 288(2014), pp. 718-726
[55] W.R. Zhou, Y.F. Zheng, M.A. Leeflang, J. Zhou.Acta Biomater, 9(2013), pp. 8488-8498
[56] L. Xu, A. Yamamoto. Appl.Surf. Sci, 258(2012), pp. 6353-6358
[57] N.J. Ostrowski, B. Lee, A. Roy, M. Ramanathan, P.N. Kumta. J. Mater. Sci.Mater. Med, 24(2013), pp. 85-96
[58] F. Witte, V. Kaese, H. Haferkamp, E. Switzer, A. Meyer-Lindenberg, C.J. Wirth, H. Windhagen.Biomaterials, 26(2005), pp. 3557-3563
[59] K.M.DeFife, K. Grako, G. Cruz-Aranda, S. Price, R. Chantung, K. MacPherson, R. Khoshabeh, S. Gopalan, W.G. Turnell. J. Biomater. Sci. Polym. Ed, 20(2009), pp. 1495-1511
[60] J. Zhou, X. Zhang, Q. Li, Y. Liu, F. Chen, L. Li. J.Mater. Chem. B, 1(2013), p. 6213
[61] L. Li, J. Gao, Y. Wang. Surf.Coat. Technol, 185(2004), pp. 92-98
[62] N. Ostrowski, B. Lee, N. Enick, B. Carlson, S. Kunjukunju, A. Roy, P.N. Kumta.Acta Biomater, 9(2013), pp. 8704-8713
[63] K. Cai, A. Rechtenbach, J. Hao, J. Bossert, K.D. Jandt.Biomaterials, 26(2005), pp. 5960-5971
[64] R. Rajaraman, D.E. Rounds, S.P.S.Yen, A. Rembaum. Exp. Cell Res, 88(1974), pp. 327-339
[65] W. Chen, T. Long, Y.J. Guo, Z.A. Zhu, Y.P. Guo. J. Mater. Chem.B, 2(2014), pp. 1653-1660
[66] A.C. Taylor. J. Cell.Bio, 15(1962), pp. 201-209
[67] Z. Zhen, X.L. Liu, T. Huang, T.F. Xi, Y.F. Zheng.Mater. Sci. Eng. C, 46(2015), pp. 202-206
[68] C.H. Ye, Y.F. Zheng, S.Q. Wang, T.F. Xi, Y.D. Li.Appl. Surf. Sci, 258(2012), pp. 3420-3427
[69] X. Wang, X. Chen, L. Xing, C. Mao, H. Yu, J. Shen. J.Mater. Chem. B, 1(2013), p. 5036
[70] N. Kong, K. Lin, H. Li, J. Chang. J.Mater. Chem. B, 2(2014), p. 1100
[71] T. Nakaki, M. Nakayama, R. Kato. Eur.J. Pharmacol, 189(1990), pp. 347-353
[72] F.C. Tanner, P. Meier, H. Greute.Circulation, 101(2000), pp. 1982-1989
[73] T.L. Cornwell, E. Arnold, N.J. Boerth.Am. J. Physiol, 1405(1994), p. 1413
[74] J.Y. Jeremy, D. Rowe, A.M. Emsley, A.C. Newby.Cardiovasc. Res, 43(1999), pp. 580-594
[75] Y.Y. Zheng, C.D. Xiong, X.Y. Li, L.F. Zhang.Appl. Surf. Sci, 320(2014), pp. 93-101

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