CdS sub-microwires with diameter of 200 nm were synthesized by a physical evaporation,Cu2S and ZnS were decorated on CdS sub-microwires as shells by immersing the CdS core into Cu+,Zn2+ and S2-solutions,respectively.The single core-shell sub-microwires were separated individually on the regular Au pattern by the photolithography technique,and then two ends of the sub-microwires were well contacted with Au electrodes by using the electron beam lithography.The photovoltaic efficiencies of 4.54％ and 1.40％ were achieved by CdS-Cu2S and CdS-ZnS core-shell heterostructure under AM 1.5 G illumination,respectively.