The hot compressive deformation behavior of hot isostatically pressed Ti-47.5Al-2Cr-2Nb-0.2W-0.2B al-loy using gas atomization powders was systematically investigated and the processing map was obtained in the temperature range of 1323-1473 K and strain rate range of 0.001-0.5 s-1 .The calculated activa-tion energy in the above variational ranges of temperature and strain rate possesses a low activation energy value of approximately 365.6 kJ/mol based on the constitutive relationship models developed with the Ar-rhenius-type constitutive model respectively considering the strain rate and deformation temperature.The hot working flow behavior during the deformation process was analyzed combined with the microstructural evolution.Meanwhile, the processing maps during the deformation process were established based on the dynamic material model and Prasad instability criterion under different deformation conditions.Finally, the optimal hot processing window of this alloy corresponding to the wide temperature range of 1353-1453 K and the low strain rate of 0.001-0.1 s-1 was obtained.